Optics: measuring and testing – Blood analysis
Patent
1989-04-07
1990-06-26
McGraw, Vincent P.
Optics: measuring and testing
Blood analysis
2504591, 356 73, 356427, G01N 3349, G01N 2164
Patent
active
049366742
ABSTRACT:
An apparatus for determining the functioning properties of cells which includes a sample containing chamber, a rotor disposed in the chamber and having a conical surface which faces the inner bottom surface of the chamber at an angle of not greater than 2.degree., a ray transmission path from which a ray is projected into a sample of a cell suspension between the rotor and the inner bottom surface, and a transmitted ray detection path from which transmittance from the sample is detected. The optical path length in the sample is not smaller than 1 cm. An adequate shear stress is applied to the sample by adjusting the gap between the rotor and the inner bottom surface and rotating the rotor. A fine response by the cells caused by the applied shear stress, particularly the aggregation of platelets in a platelet suspension, can be accurately and quantitatively determined with a high sensitivity.
REFERENCES:
Frojmovic, "Rheo-Optical Studies of Blood Cells," Biorheology, (1975) vol. 12, pp. 193-202.
O'Brien, "Platelet Aggregation," J. Clin. Path., (1962) vol. 15, pp. 446-455.
Rieger et al, "An Improved Rheological Method . . . ," Thrombosis Res., vol. 17, (1980) pp. 589-593.
Klose et al, "A Rheological Method . . . ,"Thrombosis Res., vol. 7, (1975) pp. 261-272.
Salzman, "Measurement of Platelet Adhesiveness," J. Lab. & Clin. Med., Nov. (1963), vol. 62, No. 5, pp. 724-735.
Born, "Aggregation of Blood Platelets . . . ," Nature, Jun. 9, 1962, vol. 194, No. 4832, pp. 927-929.
Grynkiewicz et al, "A New Generation of Ca.sup.2+ Indicators . . . ," J. Bio. Chem., (1985) vol. 260, No. 6, pp. 3440-3450.
Ikeda Yasuo
Itagaki Ichiro
Mikami Masato
Nagaoka Shoji
Sakai Kiyotaka
McGraw Vincent P.
Toray Industries Inc.
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