Apparatus and method for detection of fluorescence or light scat

Details Apparatus and method for detection of fluorescence or light scat Apparatus and method for detection of fluorescence or light scat

1988-04-01

1990-06-19

McGraw, Vincent P.

Optics: measuring and testing

For optical fiber or waveguide inspection

25022711, 356336, 356338, 356318, G01N 2149, G01N 2164

Patent

active

049348116

ABSTRACT:
An apparatus and method are described for defining a small interrogation volume in a liquid sample suspected of containing an analyte. The apparatus and method utilize a dual optical fiber probe constructed with the ends of the optical fibers at the liquid/fiber interface spatially oriented such that the intersection of their longitudinal axes forms an included angle ranging from about 40.degree. to 140.degree.. By appropriate choice of the numerical aperture and core diameter of the optical fibers and the separation distance between the longitudinal axes of the optical fibers at the liquid/fiber interface, a finite interrogation volume of predetermined size and independent of the total liquid sample volume can be defined. The apparatus and method substantially reduce background interference with corresponding increase in assay sensitivity.

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Abstract of Japanese Patent Appln. No. 84230306.
PCT Patent Appln. Publication No. WO85/05680, published Dec. 19, 1985.

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