Surgery – Truss – Pad
Patent
1992-08-24
1993-11-16
Smith, Ruth S.
Surgery
Truss
Pad
324312, 436 64, 436 71, 436173, A61B 5055
Patent
active
052614050
ABSTRACT:
A technique and an apparatus are disclosed for the detection of cancer using nuclear magnetic resonance (NMR). Specifically, NMR parameters for protons of lipid methyl and/or methylene groups are determined and compared against a corresponding value for healthy patients. In the preferred embodiments, an improved NMR spectrometer is employed to provide a spectrum for non-water components of blood, blood serum or blood plasma and the width of the methyl and/or methylene groups is automatically measured at half-height as a determination of spin-spin relaxation time (T.sub.2) which is the parameter used for purposes of comparison with healthy controls. Suppression of the water proton signal is employed where necessary in order to obtain a suitable spectrum for the non-water component protons. In the event that a positive reading is obtained, the level of plasma triglycerides is determined and if it is high, the patient's bodily fluid sample is further subjected to C-13 nuclear magnetic spectroscopy. The resonance line of the plasma C-13 spectra discriminates between true and false positive results from the proton NMR reading and determines the presence or absence of cancer in the patient.
REFERENCES:
patent: 3327117 (1967-06-01), Kamentsky
patent: 3420634 (1969-01-01), Godsey
patent: 3789832 (1974-02-01), Damadian
patent: 4115062 (1978-09-01), Morre et al.
patent: 4354499 (1982-10-01), Damadian
patent: 4390633 (1983-06-01), Merilan et al.
patent: 4411270 (1983-10-01), Damadian
patent: 4452250 (1984-06-01), Chance
patent: 4516074 (1985-05-01), Sugimoto
patent: 4521733 (1985-06-01), Bottomley et al.
patent: 4608991 (1986-09-01), Rollwitz
patent: 4918021 (1990-04-01), Fossel
Shulman, "NMR-Another Cancer Test Disappointment" New England Journal of Medicine, vol. 322, No. 14, Apr. 5, 1990, pp. 1002-1003.
Science News, vol. 137, p. 236, Apr. 14, 1990, "NMR Test Fails to Identify Cancer".
Wilding et al., "Assessment of Proton Nuclear Magnetic Resonance Spectroscopy for Detection of Malignancy," 34 Clinical Chemistry No. 3, 505-11 (1988).
Floyd et al., "Time Course of Tissue Water Proton Spin-Lattice Relaxation in Mice Developing Ascites Tumors," 34 Cancer Research 89-91 (Jan. 1974).
Hazlewood et al., "Relationship Between Hydration and Proton Nuclear Magnetic Resonance Relaxation Times in Tissues of Tumor-bearing and Non-Tumor-Bearing Mice: Implications for Cancer Detection," 52 J. of Nat'l Cancer Inst. No. 6, 1849-53 (Jun. 1974).
McLachlan, "Cancer-Induced Decreases in Human Plasma Proton NMR Relaxation Rates," 25Phys. Med. Biol. No. 2, 309-15 (1980).
Smith, et al., "Nuclear Magnetic Resonance Imaging of the Pancreas," 142 Radiology 677-80 (Mar. 1982).
Klimek et al., "A Discussion of Nuclear Magnetic Resonance (NMR) Relaxation Time of Tumors in Terms of Their Interpretation as Self-Organizing Dissipative Structures, and of Their Study in Vivo by NMR Zeugmatographic Imaging," 52 Ginekol Pol. No. 6, 493-502 (1981).
Beall et al., "The `Systemic Effect` of Elevated Tissue and Serum Relaxation Times for Water in Animals and Humans with Cancers," 19 NMR Basic Principles and Progress 39-57 (1981).
Wieczorek et al., "Isolation and Characterization of an RNA-Proteolipid Complex Associated with the Malignant State in Humans," 82 Proc. Nat'l Acad Sci. USA 3455-59 (May 1985).
Mountford et al., 9 J. Biochem. and Biophy, Meth. 323-30 (1984).
Mountford et al., "Influenza Virus: An NMR Study of Mechanisms Involved in Infection," 720 Biochem. Biophys. Acta 65-74 (1982).
Chamberlain, The Practice of NMR Spectroscopy 13-14, Plenum Press, New York (1974).
Onsaka et al., "Detection by Proton Nuclear Magnetic Resonance of Elevated Lactate Concentrations in Serums From Patients with Malignant Tumors," 32 Japan. J. Med. Sci. Biol. 305-9 (1979).
Mountford et al., "High Resolution Proton Nuclear Magnetic Resonance: Application to the Study of Leukaemic Lymphocytes," 41 Br. J. Cancer 1000-1003 (1980).
Mountford et al., "High-Resolution Proton Nuclear Magnetic Resonance of Metastatic Cancer Cells," 226 Science 1415-17 (1984).
Damadian, "Tumor Detection by Nuclear Magnetic Resonance," 171 Science 1151-53 (1971). Damadian discloses background information on using NMR to detect malignancy.
Frey et al., 49 J. Nat'l Cancer Inst. 903 (1972).
Inch et al., 52 J. Nat'l Cancer Inst. 353 (1974).
Iijima et al., 5 Physiol. Chem. and Physics 431 (1973).
Taylor et al., "A Review of the Magnetic Resonance Response of Biological Tissue and Its Applicability to the Diagnosis of Cancer by NMR Radiology," 5 Computed Tomography 122-33 (1981).
Zimmerman et al., "Cerebral NMR: Diagnostic Evaluation of Brain Tumors by Partial Saturation Technique with Resistive NMR," 27 Neuroradiology 9-15 (1985).
Identification and Characterization of Tissues by T.sub.2 -Selective Whole-Body Proton NMR Imaging, Magnetic Resonance in Mecicine, vol. 2., No. 29, Gersonde et al 1985.
A Proteolipid in Cancer Cells . . . , Chemical Abstracts, vol. 105, No. 11, Sep., 1986, Wright et al p. 455, col. 2, Abstract No. 95403g; and FEBS Lett., vol. 203, No. 2, 1986 pp. 164-168 Wright et al. Jul. 1986.
Proton nuclear magnetic resonance . . . , Anayltical Chemistry, Rabenstein et al, pp. 3178-3184: p. 3179, col. 2, paragraph 2, p. 3180, col. 1, paragraph 5, Dec. 1986.
NMR relaxation in human blood serum . . . , Database Biosis, (Biol. Abstracts) Abstract 76019795, Rebokatov et al and Biofizika (USSR), vol. 27, No. 2, pp. 336-338, 1982.
Proton NMR relaxation in the peripheral blood . . . , Database Biosis. abstract No. 65047264, Ekstrand et al, and Phy. Med. and Biol., vol. 22, No. 5, pp. 925-931, 1977.
Solvent Suppression in Fourier Transform Nuclear Magnetic Resonance, Hore, 55 J. Magnetic Resonance 283-300 (1983).
Holmes et al., "Hyperlipidemia as a Biochemical Basis of Magnetic Resonance Plasma Test for Cancer," 1 NMR in Biomedicine No. 1, 44-9 (1988).
Rabenstein et al., "Nuclear Magnetic Resonance Spectroscopy," 60 Analytical Chemistry No. 12, 1R-28R (Jun. 15, 1988).
Saunders et al., "A Detailed Assessment of the Recent MRS Blood Test for Cancer," Second European Conference/Congress of NMR in medicine and Biology, Berlin, Abstract 86 (Jun. 1988).
Letters to the editor, 316 New Eng. J. Med. No. 22, 1411-14 (May 28, 1987). (Authors are Parl et al., Ross et al., Small et al., Campbell et al., van Blitterswijk, and Mountford).
Dowd et al., "Detection of Malignant Tumors: Water-Suppressed Proton Nuclear Magnetic Resonance Spectroscopy of Plasma," 5 Magnetic Resonance in Medicine, No. 4, pp. 395-397 OCt. (1987).
Bruker, DISNMR Command Reference Manual, 1987.
Peeling et al., ".sup.1 H and .sup.13 C Nuclear Magnetic Resonance Studies of Plasma From Patients with Primary Intracranial Neoplasms," Journal of Neurosurgery (1988).
Smith Ruth S.
The Beth Israel Hospital Association
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