Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Reexamination Certificate
2008-07-08
2008-07-08
Gherbi, Suzette (Department: 3738)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
C623S001420
Reexamination Certificate
active
10672679
ABSTRACT:
The present invention is an apparatus and a method for delivery of mitomycin through an eluting biocompatible implantable medical device. A biocompatible drug release matrix comprises a biocompatible drug release matrix and a drug incorporated into the biocompatible drug release matrix. The drug has antibiotic and anti-proliferative properties and is an analogue related to the quinone-containing alkylating agents of a mitomycin family. The drug is initially released from the biocompatible drug release matrix at a faster rate followed by a release at a slower rate. The drug release rate maintains tissue level concentrations of the drug for at least two weeks after implantation of the medical device. The present invention provides a coating for a vascular prosthesis that elutes the drug at a controlled rate to inhibit proliferation of smooth muscle cells causing restenosis.
REFERENCES:
patent: 4642267 (1987-02-01), Creasy et al.
patent: 4978332 (1990-12-01), Luck et al.
patent: 5069899 (1991-12-01), Whitbourne et al.
patent: 5153252 (1992-10-01), Skora
patent: 5216011 (1993-06-01), Paborji et al.
patent: 5286254 (1994-02-01), Shapland et al.
patent: 5342348 (1994-08-01), Kaplan
patent: 5355832 (1994-10-01), Loh et al.
patent: 5374739 (1994-12-01), Kaneko et al.
patent: 5447799 (1995-09-01), Loh et al.
patent: 5449382 (1995-09-01), Dayton
patent: 5464650 (1995-11-01), Berg et al.
patent: 5525348 (1996-06-01), Whitbourne et al.
patent: 5534287 (1996-07-01), Lukic
patent: 5545208 (1996-08-01), Wolff et al.
patent: 5554182 (1996-09-01), Dinh et al.
patent: 5569198 (1996-10-01), Racchini
patent: 5571166 (1996-11-01), Dinh et al.
patent: 5578075 (1996-11-01), Dayton
patent: 5591227 (1997-01-01), Dinh et al.
patent: 5599352 (1997-02-01), Dinh et al.
patent: 5609629 (1997-03-01), Fearnot et al.
patent: 5624411 (1997-04-01), Tuch
patent: 5628730 (1997-05-01), Shapland et al.
patent: 5629008 (1997-05-01), Lee
patent: 5670558 (1997-09-01), Onishi et al.
patent: 5679400 (1997-10-01), Tuch
patent: 5690670 (1997-11-01), Davidson
patent: 5697967 (1997-12-01), Dinh et al.
patent: 5717030 (1998-02-01), Dunn et al.
patent: 5725567 (1998-03-01), Wolff et al.
patent: 5731087 (1998-03-01), Fan et al.
patent: 5776184 (1998-07-01), Tuch
patent: 5788979 (1998-08-01), Alt et al.
patent: 5800392 (1998-09-01), Racchini
patent: 5824048 (1998-10-01), Tuch
patent: 5824049 (1998-10-01), Ragheb et al.
patent: 5837008 (1998-11-01), Berg et al.
patent: 5837313 (1998-11-01), Ding et al.
patent: 5843172 (1998-12-01), Yan
patent: 5851217 (1998-12-01), Wolff et al.
patent: 5851231 (1998-12-01), Wolff et al.
patent: 5871535 (1999-02-01), Wolff et al.
patent: 5879697 (1999-03-01), Ding et al.
patent: 5980972 (1999-11-01), Ding
patent: 5997468 (1999-12-01), Wolff et al.
patent: 5997517 (1999-12-01), Whitbourne
patent: 6004346 (1999-12-01), Wolff et al.
patent: 6005020 (1999-12-01), Loomis
patent: 6013099 (2000-01-01), Dinh et al.
patent: 6042875 (2000-03-01), Ding et al.
patent: 6096070 (2000-08-01), Ragheb et al.
patent: 6106454 (2000-08-01), Berg et al.
patent: 6110483 (2000-08-01), Whitbourne et al.
patent: 6153252 (2000-11-01), Hossainy et al.
patent: 6156348 (2000-12-01), Santos et al.
patent: 6171609 (2001-01-01), Kunz
patent: 6179817 (2001-01-01), Zhong
patent: 6187370 (2001-02-01), Dinh et al.
patent: 6197051 (2001-03-01), Zhong
patent: 6197320 (2001-03-01), Shalaby
patent: 6203536 (2001-03-01), Berg et al.
patent: 6203551 (2001-03-01), Wu
patent: 6273908 (2001-08-01), Ndondo-Lay
patent: 6306176 (2001-10-01), Whitbourne
patent: 6316018 (2001-11-01), Ding et al.
patent: 6316522 (2001-11-01), Loomis et al.
patent: 6344035 (2002-02-01), Chudzik et al.
patent: 6346110 (2002-02-01), Wu
patent: 6358557 (2002-03-01), Wang et al.
patent: 6364856 (2002-04-01), Ding et al.
patent: 6368611 (2002-04-01), Whitbourne et al.
patent: 6387379 (2002-05-01), Goldberg et al.
patent: 6569195 (2002-05-01), Yang et al.
patent: 6399144 (2002-06-01), Dinh et al.
patent: 6419692 (2002-07-01), Yang et al.
patent: 6451348 (2002-09-01), Jeong et al.
patent: 6471980 (2002-10-01), Sirhan et al.
patent: 6482444 (2002-11-01), Bellantone et al.
patent: 6494862 (2002-12-01), Ray et al.
patent: 6503556 (2003-01-01), Harish et al.
patent: 6503954 (2003-01-01), Bhat et al.
patent: 6506437 (2003-01-01), Harish et al.
patent: 6534693 (2003-03-01), Fischell et al.
patent: 6540776 (2003-04-01), Sanders Millare et al.
patent: 6544582 (2003-04-01), Yoe
patent: 6545097 (2003-04-01), Pinchuk et al.
patent: 6730313 (2004-05-01), Helmus et al.
patent: 6733767 (2004-05-01), Chern et al.
patent: 7160592 (2007-01-01), Rypacek et al.
patent: 2001/0001824 (2001-05-01), Wu
patent: 2001/0014717 (2001-08-01), Hossainy et al.
patent: 2001/0018469 (2001-08-01), Chen et al.
patent: 2001/0018919 (2001-09-01), Kutzko et al.
patent: 2001/0044651 (2001-11-01), Steinke et al.
patent: 2001/0049349 (2001-12-01), Chinery et al.
patent: 2002/0018795 (2002-02-01), Whitbourne et al.
patent: 2002/0052404 (2002-05-01), Hunter et al.
patent: 2002/0055666 (2002-05-01), Hunter et al.
patent: 2002/0082682 (2002-06-01), Barclay et al.
patent: 2002/0123505 (2002-09-01), Mollison et al.
patent: 2002/0123788 (2002-09-01), Millare et al.
patent: 2002/0123801 (2002-09-01), Pacetti et al.
patent: 2002/0133224 (2002-09-01), Bajgar et al.
patent: 2002/0155092 (2002-10-01), Leong et al.
patent: 2002/0165423 (2002-11-01), Forman
patent: 2002/0183763 (2002-12-01), Callol et al.
patent: 2002/0193475 (2002-12-01), Hossainy et al.
patent: 2003/0004564 (2003-01-01), Elkins et al.
patent: 2003/0017190 (2003-01-01), Sirhan et al.
patent: 2003/0027863 (2003-02-01), Cruz et al.
patent: 2003/0040712 (2003-02-01), Ray et al.
patent: 2003/0040790 (2003-02-01), Furst et al.
patent: 2003/0054090 (2003-03-01), Hansen
patent: 2003/0065382 (2003-04-01), Fischell et al.
patent: WO 03/064944 (2003-05-01), None
International Search Report based on PCT/US03/30613 dated Jul. 9, 2004.
Strauss et al., “Late Effects of Locally Delivered Mitomycin C on Formation of Neointima and on Vasomotor Response to Acetylcholine”, Jul. 1994,Coronary Artery Disease, vol. 5 No. 7, p. 633-641.
Furnish Simon M.
Granada Juan F.
Dykeman David J.
Endovascular Devices, Inc.
Gherbi Suzette
Greenberg & Traurig, LLP
LandOfFree
Apparatus and method for delivery of mitomycin through an... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Apparatus and method for delivery of mitomycin through an..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Apparatus and method for delivery of mitomycin through an... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3907459