Chemistry: electrical and wave energy – Apparatus – Electrophoretic or electro-osmotic apparatus
Reexamination Certificate
2007-10-16
2007-10-16
Nguyen, Nam (Department: 1753)
Chemistry: electrical and wave energy
Apparatus
Electrophoretic or electro-osmotic apparatus
C204S450000, C435S287100, C435S287200
Reexamination Certificate
active
10355347
ABSTRACT:
The present invention provides an apparatus and method for controlling the movement of a biopolymer translocating a nanopore. The invention provides a first electrode, a second electrode adjacent to the first electrode, a third electrode adjacent to the second electrode and a fourth electrode adjacent to the third electrode. The first electrode is in electrical connection with the third electrode to define a first set of electrodes and the second electrode is in electrical connection with the fourth electrode to define a second set of electrodes. A DC voltage and radio frequency voltage is applied to the first set of electrodes while an opposite DC voltage and phase shifted radio frequency voltage is applied to the second set of electrodes to produce an electric field between the first set of electrodes and the second set of electrodes. The electric field is used to control the movement of a biopolymer translocating a nanopore. A method for controlling the movement of a biopolymer is also disclosed.
REFERENCES:
patent: 6051380 (2000-04-01), Sosnowski et al.
patent: 6245508 (2001-06-01), Heller et al.
patent: 6627067 (2003-09-01), Branton et al.
patent: 2002/0119455 (2002-08-01), Chan
patent: 2002/0182627 (2002-12-01), Wang et al.
patent: 2002/0197618 (2002-12-01), Sampson
patent: 2004/0033492 (2004-02-01), Chen
patent: WO 02/42496 (2002-05-01), None
patent: WO 03/000920 (2003-01-01), None
patent: WO 03/003446 (2003-01-01), None
Li et al., “Ion-Beam Sculpting at Nanometre Length Scales”, (2001), Macmillan Magazine Ltd., vol. 412, pp. 166-169.
Akeson et al., “Microsecond Time-Scale Discrimination among Polcytidylic Acid, Poladenylic Acid, and Polyurdylic Acid as Homopolymers or as Segments within Single RNA Molecules”, (1999), Biophysical Journal, vol. 77, pp. 3227-3233.
Kasianowicz et al., “Characterization of Individual Polynucleotide Molecules using a Membrane Channel”, (1996), Proc. Natl. Acad. Sci. USA, vol. 93, pp. 13770-13773.
European Search Report Dated: Feb. 27, 2004.
Agilent Technologie,s Inc.
Barton Jeffrey
Nguyen Nam
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