Apparatus and method for continuous centrifugal blood cell separ

Liquid purification or separation – Processes – Separating

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210 95, 2101981, 2103801, 210514, 2105321, 210789, 422 72, 422101, 422 1, 436 45, 436 63, 436177, 436180, 494 27, 494 34, 494 43, B01D 2126

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051868440

ABSTRACT:
An analytical rotor for separating cellular components from a biological fluid includes a separation chamber spaced radially outward from a sample chamber. The sample chamber may be an open receptacle disposed to receive sample or may be a mixing chamber which receives sample and diluent. A flow restrictive channel connects the sample chamber to the separation chamber so that fluid enters the separation chamber at a controlled rate. The cellular components collect within a retention region located generally at the outer periphery of the collection chamber while cell-free fluid is continuously removed through a collection port. The collection port is spaced annularly apart from the flow channel so that there is sufficient residence time within the separation chamber for substantially complete separation of the cells from the fluid fraction. In a first embodiment, a collection chamber is attached through the collection port through an annular flow channel, while in a second embodiment a collection chamber is connected through a vertical flow channel.

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