Apparatus and method for concurrently monitoring active...

Details Apparatus and method for concurrently monitoring active... Apparatus and method for concurrently monitoring active...

2006-04-04

2006-04-04

Williams, Hezron (Department: 2856)

Measuring and testing

Testing of material

Reexamination Certificate

active

07021163

ABSTRACT:
An apparatus and method for monitoring the dissolution properties of a solid dosage form pharmaceutical or other material. The apparatus includes a hollow dissolution chamber for supporting the dosage form and subjecting it to a dissolution liquid so that the dosage form dissolves in the liquid. A dissolution liquid analyzing device (e.g., a spectrophotometer) analyzes the properties of the dissolution liquid as the dosage form dissolves. A video monitoring means (e.g., a stereo-microscope and video camera) provides a series of images of the dosage form as it dissolves. The series of images and data resulting from the analysis are recorded and correlated. The temperature, flow rate and chemical parameters of the dissolution liquid can be controlled (e.g., held constant or altered), if desired.

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