Apparatus and method for compound profiling of living cells

Details Apparatus and method for compound profiling of living cells Apparatus and method for compound profiling of living cells

1999-05-24

2000-08-01

Leary, Louise N.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving viable micro-organism

435 4, 435 71, 4352831, 422 50, 422 681, 36414805, 36452801, C12Q 102, C12Q 100

Patent

active

060965096

ABSTRACT:
An apparatus and method for real-time measurement of a cellular response of a test compound or series of test compounds (303) on a flowing suspension of cells (349), in which a homogeneous suspension of each member of a series of cell types (349) is combined with a concentration of a test compound (303), directed through a detection zone (355), and a cellular response of the living cells is measured in real time as the cells in the test mixture are flowing through the detection zone (355). The apparatus may be used in automated screening of libraries of compounds, and is capable of real-time variation of concentrations of test and standard compounds and generation of dose/response profiles within a short timespan.

REFERENCES:
patent: 5919646 (1999-07-01), Okun et al.

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