Apparatus and method for antibody screening, typing and compatib

Chemistry: physical processes – Physical processes – Crystallization

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422 61, 422 68, 422 72, 422102, 424 11, 424 12, 23915, G01N 3502, G01N 3354, G01N 3380

Patent

active

042525381

ABSTRACT:
A dual cavity substrate having a sample compartment for selectively discharging the fluid under test is rotatably mounted in a holder. A monolayer of red blood cells is centrifugally developed on the cavity surfaces of the substrate and, after typing, is subjected to the presence of an antibody which antibody may or may not have an affinity for the antigen of the first layer of red blood cells. A second monolayer of red blood cells is layed on the antibody. One of the two layers of blood cells or the antibody is the element being tested. Should agglutination of the second layer of red blood cells occur, the test is positive. Equipments for various substrate surface preparation procedures as well as for washing, lysing and optical inspection procedures are also described. A method for conducting various tests performable by the apparatus is disclosed.

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patent: 4055394 (1977-10-01), Friedman
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patent: 4119407 (1978-10-01), Goldstein

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