Chemistry: analytical and immunological testing – Composition for standardization – calibration – simulation,...
Patent
1991-02-27
1993-09-21
Warden, Robert J.
Chemistry: analytical and immunological testing
Composition for standardization, calibration, simulation,...
436 34, 436164, 436165, 422 56, 422 8205, 422 8209, 422 58, 422 681, 356445, 356446, G01N 3100, G01N 2100
Patent
active
052468585
ABSTRACT:
A method and apparatus (10) for determining the remission of a chemistry (106) which reacts with a medically significant component of a body fluid. The remission of the chemistry (106) changes as it reacts. The method and apparatus (10) include irradiating the chemistry (106) with a radiation source (182), detecting remissions of radiation from the chemistry (106) with a radiation detector (300), providing a radiation pathway (164) between the source (182) and the chemistry (106), providing a remission pathway (164) between the chemistry (106) and the detector (300), and detecting the rate of change of remission of the chemistry (106) with respect to time. The irradiating, detecting and rate detecting steps and apparatus comprise initially irradiating the chemistry (106) at a first time rate and detecting remissions therefrom, comparing remission data from remission readings spaced apart by a first number of intervening remission readings, and determining when the difference between compared readings exceeds a first predetermined limit. The time rate of irradiation of the chemistry is changed once the difference between compared readings exceeds the first limit. Remission data from remission readings spaced apart by a second number of intervening remission readings are then compared. The method and apparatus next determine when the difference between compared readings no longer exceeds a second predetermined limit. The last remission reading is then converted to the concentration of the medically significant component of the body fluid.
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Arbuckle Steven R.
Boyd William R.
Grant Michael E.
Gray Russell T.
Gregory Mark A.
Boehringer Mannheim Corporation
Kim Christopher Y.
Warden Robert J.
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