Electricity: measuring and testing – Particle precession resonance – Spectrometer components
Patent
1982-09-28
1985-04-09
Levy, Stewart J.
Electricity: measuring and testing
Particle precession resonance
Spectrometer components
324308, G01R 3308
Patent
active
045104506
ABSTRACT:
An assay method for the quantitative determination of the mineral content of bone comprises using proton decoupling and magic angle sample spinning techniques to record well resolved .sup.31 P nuclear magnetic resonance spectra of unfractionated bone biopsy samples and characterizing the differences in mineral identity and content from those of normal bone. A rotor for performing the assay includes a compartment for the sample to be assayed, and a separate compartment for a reference material.
REFERENCES:
patent: 3329890 (1967-07-01), Kingston
patent: 3427532 (1962-02-01), Nelson
patent: 4254373 (1981-03-01), Lippmaa et al.
patent: 4275350 (1981-06-01), Hill et al.
"Determination of Magnetic Moments in Solution by NMR Spectrometry", R. Engel et al., Analytical Chemistry, vol. 45, #2, Feb. 1973, pp. 367-369.
"Purification, Composition & .sup.31 P NMR Spectroscopic Properties of a Noncollageneous Phoprotien Isolated from Chicken Bone Matrix", Lee et al., Calcification Tissue International, 1981, 33 (4), pp. 385-394.
"High Speed Spinner for Magic Angle Spinning NMR", Van Dijk et al., Institute of Physics, Scientific Instrs., vol. 13, #12, Dec. 1980.
High Resolution NMR Spectroscopy, Emsleg et al., pp. 1052--1078.
"NMR Probe for Combined Hemonuclear Multiple Pulse Decoupling and Magic Angle Spinning", by R. G. Pembleton et al. in Rev. Sci. Instrum., vol. 48, No. 10, pp. 1286-1289, (1977).
"High-Resolution Variable-Temperature .sup.31 P NMR of Solid Calcium Phosphates", by W. P. Rothwell et al. in J. Am. Chem. Soc., 102(8):2637-2643, (1980).
"Magic Angle Sample Spinning in Inhomogeneously Broadened Biological Systems", by J. Herzfeld et al. in Phil. Trans. R. Soc. Land., B 289, 459-469, (1980).
"High-Speed Rotors for Nuclear Magnetic Resonance Studies on Solids," Andrew, E. R., Farnell, L. F., Firth, M., Gledhill, T. D., and Roberts, I., J. Magn. Reson., 1, 27, 1969.
"NMR Probe for Combined Homonuclear Multiple Pulse Decoupling and Magic Angle Spinning", Pembleton, R. G., Ryan, L. M., and Gerstein, B. C., Rev. Sci. Instrum., 48, 1286, 1977.
"A High-Speed Magic Angle Spinner", Zilm, K. W., Alderman, D. W., and Grant, D. M., J. Magn. Reson., 30, 563, 1978.
"A Simple `Magic-Angle` Spinning Apparatus for Routine Use in NMR Spectroscopy of Solids", Fyfe, C. A., Mossbruger, H., and Yannoni, C. S., J. Magn. Reson., 36, 61, 1979.
"Spinning Apparatus for Nuclear Magnetic Resonance Spectrometers, and Spectrometer Incorporating this Spinning Apparatus", Fyfe, C. A., Mossbruger, H. G., and Yannoni, C., Chemical Abstracts, vol. 93, 1980, 93: 849644.
"High--Resolution Proton NMR in Solids with Multiple--Pulse Sequences and Magic--Angle Sample Spinning at 270 MHz", Scheler, G., Haubenreisser, U., and Rosenberger, H., J. Magn. Reson., 44, 134, 1981.
Levy Stewart J.
The Medical College of Wisconsin Inc.
LandOfFree
Apparatus and assay method for the quantitative determination of does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Apparatus and assay method for the quantitative determination of, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Apparatus and assay method for the quantitative determination of will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1172095