Apparatus and analysis for agglutination reaction

Chemistry: physical processes – Physical processes – Crystallization

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232303, 1951035R, 233 1R, 356 39, 356427, 424 1, 424 11, 422 72, 422 79, G01N 3316, G01N 2160, G01N 3102, G01N 3114

Patent

active

041486072

ABSTRACT:
Analysis of and apparatus for studying simple or complex agglutination reactions, such as for blood analysis and in particular blood groupings in which the specimen is mixed with at least one reagent in a vessel of predetermined shape and this mixture is incubated and thereafter centrifuged in this vessel. The nature of the reaction, the operations performed on the mixture and the shape of the vessel are such as to provide at cessation of the centrifuging the accumulation of the agglutinated particles at a particular location in the vessel. Following a waiting period in which the mixture is given the opportunity to partly or substantially entirely move under the influence of gravity away from said location, the path of said movement is observed by an optical arrangement which enables determination of the nature of the reaction, i.e. the presence or absence of agglutinated or non-agglutinated elements is observed after a time interval sufficient to permit their separation.

REFERENCES:
patent: 3488156 (1970-01-01), Good
patent: 3586484 (1971-06-01), Anderson
patent: 3677710 (1972-07-01), Hirsch
patent: 3759666 (1973-09-01), Hill
patent: 3770380 (1973-09-01), Smith
patent: 3838809 (1974-10-01), Williams
patent: 3841838 (1974-10-01), Natelson
patent: 3883308 (1975-05-01), Matte
patent: 3899296 (1975-08-01), Mailen
patent: 3970427 (1976-07-01), Esposito
"Gradwohl's Clinical Laboratory Methods", S. Frankel, ed., vol. 1, 7th Edition, 756-757, C. V. Mosby, St. Louis, 1970.

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