Apovincaldehyde

Details Apovincaldehyde Apovincaldehyde

1975-06-05

1977-01-04

Todd, G. Thomas

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07D45900

Patent

active

040012514

ABSTRACT:
Vincamine and/or its stereoisomers, a known drug, is made from vincaminol and/or its stereoisomers by successive conversion of the latter into apovincaldehyde, apovincamine, and 16-methoxycarbonyl-eburnane, followed by conversion of the last into vincamine either directly by introduction of a 16-hydroxyl group or by hydrolysis, introduction of a 16-hydroxyl group, and re-esterification.

REFERENCES:
blaha et al., Collect. Czech. Chem. Commun. 1968, 33 (11), 3833-3847, C.A. 70: 29146h (1969).

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