Apoptotic regression of intimal vascular lesions

Details Apoptotic regression of intimal vascular lesions Apoptotic regression of intimal vascular lesions

1996-08-08

1998-07-07

Marschel, Ardin H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

435 691, A61K 4800

Patent

active

057769052

ABSTRACT:
Neointimal cells are shown to express high levels of an anti-apoptotic gene, bcl-x, while the medial cells of the vessel itself express only low levels. The difference in gene expression exploited to provide for selective deletion of the neointimal cells. Apoptosis is induced by administering anti-sense bcl-x oligonucleotides to the affected vessel. Apoptosis is desirable as a treatment because it does not induce inflammation, further tissue injury or reactive hyperplasia. A significant reduction in lesion size is seen after treatment.

REFERENCES:
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