Apoptotic peptides

Details Apoptotic peptides Apoptotic peptides

1998-03-20

2000-10-03

Slobodyansky, Elizabeth

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Method of regulating cell metabolism or physiology

435 691, 435 697, 435455, 436 86, 514 44, C12N 510, C12P 2106, C12P 2104, G01N 3300, A01N 4304

Patent

active

061271780

ABSTRACT:
Apoptosis-promoting recombinant Id polypeptides comprise an Id N-terminus domainpeptides comprise an Id N-terminus domain peptide comprising an effective portion of the N-terminal domain of a natural Id protein. The polypeptides may be produced recombinantly from transformed host cells from the subject recombinant Id polypeptide encoding nucleic acids. The invention provides methods of making and using the subject compositions and mimic thereof to modulate cellular physiology, and especially promote apoptosis and in the biopharmaceutical industry.

REFERENCES:
Verma et al. (Sep. 18, 1997) Nature, vol. 389, pp. 239-242.
Lasorella et al. (1996) Molecular and Cellular Biology, vol. 16, pp. 2570-2578.

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