Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1994-12-23
1998-07-21
Achutamurthy, Ponnathapura
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
4241841, 4241301, 5303873, C07K 100, C12P 2108, A61K 3900, A61K 39395
Patent
active
057836671
ABSTRACT:
Apoptosis or programmed cell death is a tightly regulated mechanism used by the body to eliminate excess cells in a given tissue. If this mechanism fails, resulting in too many cells, cancer may develop in certain tissues. If the mechanism is overactive, resulting in the destruction of too many cells, tissue degeneration can occur. Therefore being able to identify which cells are destined to undergo apoptosis is critical in allowing clinicians, pathologists and researchers to develop means to detect, diagnose or treat disorders wherein the natural regulation of cell death events is interrupted. The present inventor has identified a 30 kDa protein, designated Tp30, that is specific for cells that are programmed to die. A monoclonal antibody specific for Tp30 has also been identified. The Tp30 protein and monoclonal antibodies thereto are useful in the detection and therapy of disorders wherein the natural regulation of cell death events is interrupted. Such disorders include cancer, bone degeneration, autoimmune diseases, neurodegenerative diseases, cardiovascular disorder, ischemia, HIV-associated illness and kidney malfunction.
REFERENCES:
Schipper et al; Expression of terminin, a sequence-related cytoplasmic protein, in the aging rat brain; Brain Research; vol. 635; pp. 224-230; 1994.
Wang et al; Granula Presence of Terminin is the Marker to Distinguish Between the Senescent and Quiescent States; Journal of Cellular Physiology; vol. 147; pp. 514-522; 1991.
Mitmaker et al; Temporal realationships of statin and terminin expression in ventral lobe of rat prostate prostate following castration; European Journal of Histochemistry; vol. 37; pp. 295-301; 1993.
Wang et al; Control of Fibroblase Senescence and Activation of Programmes Cell Death; Journal of Cellular Biochemistry; vol. 54; pp. 432-439; 1994.
Yang et al; Expression of terminin in the rat brain during neuronal differenttiation; Brain Research; vol. 615; pp. 71-79; 1993.
Yang et al; Terminin (Tp 63/60), a novel cell senescence-related protein, is present in the aging human hippocampus; Brain Research; vol. 644; pp. 188-196; 1994.
Hebert et al; Commitment to Cell Death is Signaled by the Appearence of Terminin Protein of 30 kDa; Experimental Cell Research; vol. 210; pp. 10-18; 1994.
Achutamurthy Ponnathapura
Cooper Iver P.
Park Hankyel T.
Sir Mortimer B. Davis-Jewish General Hospital
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