Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-08-29
1997-11-25
Goldberg, Jerome D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514249, 514250, 514251, 514255, A61K 31495, A61K 3150, A61K 31525
Patent
active
056913419
ABSTRACT:
Apoptosis regulating compositions each comprising a member selected from a series of carbostyril derivatives and salts thereof, inclusive of carbostyril derivatives of general formula (1) ##STR1## and salts thereof, as an active ingredient are provided. The apoptosis regulating compositions of the invention are of use as anticancer agents, antiretrovirus agents, therapeutic agents for autoimmune diseases, therapeutic agents for thrombocytopenia, therapeutic agents for Alzheimer's disease, therapeutic agents for diseases of the liver, and cancer metastasis inhibitors, among others.
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Levine et al., Elevated Circulating Levels of Tumor Necrosis Factor in Severe Chronic Heart Failure, The New England Journal of Medicine, vol. 323, Jul. 1990, pp. 236-241.
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Adachi Masakazu
Aihara Koutoku
Akamatsu Seiji
Iba Hitomi
Ichikawa Hiroyuki
Goldberg Jerome D.
Otsuka Pharmaceutical Co. Ltd.
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