Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...
Reexamination Certificate
2011-07-05
2011-07-05
Davis, Zinna N (Department: 1625)
Organic compounds -- part of the class 532-570 series
Organic compounds
Nitrogen attached directly or indirectly to the purine ring...
C544S121000
Reexamination Certificate
active
07973161
ABSTRACT:
Disclosed are compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression one or more than one of an anti-apoptotic protein family member.
REFERENCES:
patent: 5138069 (1992-08-01), Carini et al.
patent: 6410584 (2002-06-01), Pamukcu et al.
patent: 6720338 (2004-04-01), Augeri et al.
patent: 7030115 (2006-04-01), Elmore et al.
patent: 7358251 (2008-04-01), Elmore et al.
patent: 7390799 (2008-06-01), Bruncko et al.
patent: 7449485 (2008-11-01), Elmore et al.
patent: 7504512 (2009-03-01), Augeri et al.
patent: 7585858 (2009-09-01), Elmore et al.
patent: 7642260 (2010-01-01), Bruncko et al.
patent: 2002/0086887 (2002-07-01), Augeri et al.
patent: 2003/0119894 (2003-06-01), Murthy et al.
patent: 2006/0258657 (2006-11-01), Bruncko et al.
patent: 2007/0015787 (2007-01-01), Bruncko et al.
patent: 2008/0076779 (2008-03-01), Elmore et al.
patent: 2008/0287419 (2008-11-01), Bruncko et al.
patent: 230136 (1991-12-01), None
patent: 0224636 (2002-03-01), None
patent: 02098848 (2002-12-01), None
patent: 03040107 (2003-05-01), None
patent: WO03080586 (2003-10-01), None
patent: 2004043950 (2004-05-01), None
patent: 2004048329 (2004-06-01), None
patent: WO 2005/049594 (2005-06-01), None
patent: WO2005049593 (2005-06-01), None
Thomas H. Corbett, et al., “Discovery and Preclinical Antitumor Efficacy Evaluations of LY32262 and LY33169”, Investigational New Drugs, Feb. 21, 2003, vol. 31: pp. 33-45.
Degterev, et al., “Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL,” Nature Cell Biology, vol. 3, Feb. 2001, pp. 173-182.
Enyedy, et al., “Discovery of Small-Molecule inhibitors of Bcl-2 through Structure-Based Computer Screening,” J. Med. Chem., 2001, 44, 4313-4324.
ISA, PCT International Preliminary Report on Patentability dated May 15, 2006, in International Application No. PCT/US2004/036770, filed Nov. 3, 2004.
ISA, PCT International Preliminary Report on Patentability dated May 15, 2006, in International Application No. PCT/US2004/037911, filed Nov. 12, 2004.
ISA, PCT International Search Report dated May 13, 2005, in International Application No. PCT/US2004/036770, filed Nov. 3, 2004.
ISA, PCT International Search Report dated May 13, 2005, in International Application No. PC1/US2004/037911, filed Nov. 12, 2004.
Kutzki, et al., “Development of Potent Bcl-xl Antagonist Based on α-Helix Mimicry,” J. Am. Chern. Soc., 2002, 124, 11838-11839.
Tse et al., “ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor,” May 1, 2008, Cancer Research 68(9):3421-3428.
Wang, et al., “Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells,” PNAS, Jun. 20, 2000, vol. 97, No. 13, pp. 7124-7129.
Wang, et al., “A novel small molecule inhibitor of Bcl-XLinhibits tumor growth in a human head and neck squamous cell carcinoma xenograft model,” Proceedings of the American Association for Cancer Research, vol. 44, 2ndEd., Jul. 2003, p. 942, #4740.
Amendment and Response filed on Oct. 8, 2009 in U.S. Appl. No. 11/600,445.
Banker, Gilbert S. et al., “Modem Pharmaceutics, Marcel Dekker”, 1996.
Final Office Action dated Aug. 12, 2009 for U.S. Appl. No. 12/120,914.
Hattori et al., CAS Accession No. 2006: 298664, 2006.
Non-final Office Action dated Nov. 28, 2008 for U.S. Appl. No. 12/120,914.
Oltersdorf et al., “An inhibitor of Bcl-2 family proteins induces regression of solid tumours,” Nature, 2005, 435.
Wang G., et al., “An Efficient Synthesis of ABT-263, a Novel Inhibitor of Antiapoptotic Bcl-2 Proteins”, Synthesis, 2008, 15, 2398-2404.
Wolff, Mandred E., “Burger's Medicinal Chemistry and Drug Discovery,” Principles and Practice, 1995, 975-977, 5th Ed,vol. 1, John Wiley & Sons.
Bruncko Milan
Ding Hong
Elmore Steven
Kunzer Aaron
Lynch Christopher L.
Abbott Laboratories
Davis Zinna N
Jones Day
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