Apoptosis modulator BCL-B and methods for making and using same

Details Apoptosis modulator BCL-B and methods for making and using same Apoptosis modulator BCL-B and methods for making and using same

2009-04-20

2010-12-07

Cheu, Jacob (Department: 1641)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C435S007200

Reexamination Certificate

active

07846681

ABSTRACT:
A novel human member of the Bcl-2 family Bcl-B has been identified, which is closest in amino-acid sequence homology to the Boo (Diva) protein. The Bcl-B protein is widely expressed in adult human tissues. The Bcl-B protein modulates apoptosis. Bcl-B also binds Bcl-2. BCl-XL, and Bax but not Bak. Bcl-B displays a unique pattern of selectivity for binding and regulating the function of other members of the Bcl-2 family. Accordingly, provided herein is a method for identifying a molecule that binds to the Bcl-B polypeptide, by contacting the Bcl-B polypeptide with a test molecule and determining whether the test molecule binds to the polypeptide.

REFERENCES:
patent: 6582908 (2003-06-01), Fodor et al.
patent: WO 8403564 (1984-09-01), None
patent: WO 0000506 (2000-01-01), None
Mine et al. (FEBS Letters 1999 vol. 448, p. 33-37).
Ke et al.; Bcl-B, a Novel Bcl-2 Family Member That Differentially Binds and Regulates Bax and Bak; The Journal of Biological Chemistry, vol. 276, No. 16; Apr. 2001; p. 12481-12484.
Aouacheria et al.; Nrh, a human homologue of Nr-13 associates with Bcl-Xs and is an inhibitor of apoptosis; Oncogene, vol. 20; 2001; p. 5846-5855.
Zhang et al.; Bcl2-L-10, a novel anti-apoptotic member of the Bcl-2 family, blocks apoptosis in the mitochondria death pathway but not in the death receptor pathway; Human Molecular Genetics, vol. 10, No. 21; 2001; p. 2329-2339.
Bouillet et al., BH3-only proteins—evolutionarily conserved pro-apoptotic Bcl2 family members essential for initiating programmed cell death; Journal of Cell Science, vol. 115; 2002; p. 1567-1574.
Anderson, Human gene therapy, (Nature 1998; 392(suppl):25-30).
Dang et al., Gene Therapy and Translational Cancer Research, (Clinical Cancer Research 1999; 5:471-474).
Levine et al., Toward Gene Therapy of Diabetes Mellitus, (Molecular Medicine Today 1999; 5:165-171).

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