Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1995-12-28
1998-04-28
Owens, Amelia
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
514 89, 514351, 514458, 514702, A61K 3115
Patent
active
057444994
ABSTRACT:
Apoptosis (programmed cell death) in mammalian organisms is modulated, whether initiated or suppressed, for example for preventing and/or combating photoinduced or chronologic aging of the skin or for treating a wide variety of human afflictions, by administering thereto, for such prolonged period of time as is required to elicit the desired response, an effective apoptosis-modulating amount of at least one active species selected from among methional, malondialdehyde, or factor influencing the intracellular concentration of methional or malondialdehyde.
REFERENCES:
Biochem. J., vol. 305, No. pt. 3, 1995, pp. 1017-1025, G. Quash et al., "Methional derived from 4-methylthio-2-oxobutanoate is a cellular mediator of apopotosis in baf3 lymphoid cells."
Biochem. Pharmacol., vol. 45, No. 8, 1993, pp. 1631-1644, G. Ogier et al., "Contribution of 4-methylthio-2-oxobutanoate and its transaminase to the growth of methionine-dependent cells in culture: effect of transaminase inhibitors."
Chem. Biol. Interact., vol. 50, No. 1, 1984, pp. 87-96, F.W. Summerfield et al., "Cross-linking of DNA in liver and testes of rats fed 1,3-propanediol."
J. Neurobiol., vol. 24, No. 4, 1993, pp. 433-446, M.D. Linnik et al., "Induction of programmed cell death in a dorsal root ganglia X neuroblastoma cell line."
J. Neurosci., vol. 14, No. 7, 1994, pp. 4385-4392, R.R. Ratan et al., "Macromolecular synthesis inhibitors prevent oxidative stress-induced apoptosis in embryonic cortical neurons by shunting cysteine from protein synthesis to glutathione."
Doutheau Alain
Quash Gerard Anthony
Centre International de Recherches Dermatologiques Galderma
Owens Amelia
LandOfFree
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