Apoptosis inhibitors

Details Apoptosis inhibitors Apoptosis inhibitors

2006-03-10

2010-10-19

Andres, Janet L (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S253110, C514S235500, C514S357000, C514S343000, C514S253060, C514S314000, C514S311000, C514S307000, C514S253050, C544S128000, C544S363000, C544S360000, C544S124000, C546S276400, C546S159000, C546S201000, C546S145000, C546S338000

Reexamination Certificate

active

07816352

ABSTRACT:
The present invention provides compounds that act as selective agents to protect against unintentional cell death or tissue damage and can relieve side effects of cancer treatment such as, for example, oral mucositis, hair loss, diarrhea due to damage to the gastrointestinal epithelium, and myelosuppression. In addition, these compounds can be used to prevent premature cell death when the cell death is caused by signals from damaged cells, for example, signals generated as the result of a traumatic incident or an ischemic episode.

REFERENCES:
patent: WO-2006/099301 (2006-09-01), None
patent: WO-2006/099301 (2006-09-01), None
patent: WO-2006099301 (2006-09-01), None
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Hcaplus 2005:244454, “Quinolinium salt as a potent inhibitor of lymphocyte apoptosis”, Barchechath et. al., Bioorganic & Medicinal Chemistry Letters article accepted Feb. 16, 2005.
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Karljikovic-Rajic, K. , et al., “Silver Electrode in Direct Potentiometric Determination of 4′- and 6-methyl derivatives of 1-(2-phenyl-2-hydroxyiminoethyl)-1-quinolinium chloride”,Journale de Pharmacie de Belgique.
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Karljikovic-Rajic, K. , et al., “Silver Electrode in Direct Potentiometric Determination of 4′- and 6′-methyl derivatives of 1-(2-phenyl-2-hydroxyiminoethyl)-1-quinolinium chloride”,Journale de Pharmacie de Beligique, 42(4), (1987), Abstract Only, Chemical Abstracts Doc. No. 108:33102, 2 p.

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