Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1999-03-15
2000-07-11
Gerstl, Robert
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514376, 548183, A01K 31426, A01K 31427
Patent
active
060873841
ABSTRACT:
An apoptosis inhibitor which comprises a compound of the formula: wherein R represents a hydrocarbon group that may be substituted or a heterocyclic group that may be substituted; Y represents a group of the formula: --CO--, --CH(OH)-- or --NR.sup.3 -- where R.sup.3 represents an alkyl group that may be substituted; m is 0 or 1; n is 0, 1 or 2; X represents CH or N; A represents a chemical bond or a bivalent aliphatic hydrocarbon group having 1 to 7 carbon atoms; Q represents oxygen or sulfur; R.sup.1 represents hydrogen or an alkyl group; ring E may have further 1 to 4 substituents, which may form a ring in combination with R.sup.1 ; L and M respectively represent hydrogen or may be combined with each other to form a chemical bond; or a salt thereof, or a compound having an insulin sensitivity enhancing activity.
REFERENCES:
patent: 5457109 (1995-10-01), Tammy et al.
patent: 5602133 (1997-02-01), Tammy et al.
patent: 5663389 (1997-09-01), Tammy et al.
patent: 5726055 (1998-03-01), Hindley
A.Okuno et al., "Effects of Thiazolidinediones on Adipose Tissue . . . ," The Saishin-Igaku, Jun. '97, vol.52(6), pp. 1153-1160, with its English translation.
K. Suzuki, PhD and M. Yokota, MD, "Apoptosis-up to date-Chairman's introductory Remarks, 36th General Assembly of the Tokai-Hokuriku Branch, Japan Society of Clinical Pathology," Japanese Journal of Clinical Pathology, 45:603-605, 1997.
J. Larm et al., "(S)-5 Fluorowillardiine-medicated neurotoxicity in cultured murine cortical neurones occurs via AMPA and kainate receptors," European J. of Pharmacology314(1996) pp.249-254.
H. Kizaki, "Apoptosis and Disease," Igaku No Ayumi (J. of Clinical and Experimental Medicine) 178(10): 712-716, 1996, with its English translation.
Y. Nagasaka et al., "The new oral hypoglycemic agent CS-045, . . . ," Biochemical Pharmacology, vol.50, No. 7, Sep. 28, 1995, pp. 1109-1111.
Ohtani Endocrinology 139 (1) 172-9, Jan. 1998.
Matsui Junji
Momose Yu
Naruo Ken-ichi
Tarui Naoki
Gerstl Robert
Riesen Philippe Y.
Sohn Miriam
Takeda Chemical Industries Ltd.
LandOfFree
Apoptosis inhibitor does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Apoptosis inhibitor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Apoptosis inhibitor will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-542808