Apoptosis-inducing polypeptides

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

Reexamination Certificate

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C424S184100

Reexamination Certificate

active

07323546

ABSTRACT:
An isolated water-soluble VP1 polypeptide of foot-and-mouth disease virus and a nucleic acid encoding the polypeptide. Also disclosed are a pharmaceutical composition containing the polypeptide or nucleic acid and related methods of inducing apoptosis and treating an apoptosis-related disorder.

REFERENCES:
Jackson et al. Journal of Virology. 1997; 71 (11): 8357-61.
Shieh et al. Vaccine. 2001; 19: 4002-4010.
Jackson et al. “Arginine-Glycine-Aspartic Acid-Specific Binding by Foot-and-Mouth Disease Viruses to the Purified Integrin αvβ3 In Vitro”. Journal of Virology 71(11):8357-8361, Nov. 1997.
Carmen M. Ruiz-Jarabo et al. “Antigenic properties and population stability of a foot-and-mouth disease virus with an altered Arg-Gly-Asp receptor-recognition motif.” Journal of General Virology 80:1899-1909, 1999.

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