Apoptosis-inducing agent and method for inducing apoptosis

Details Apoptosis-inducing agent and method for inducing apoptosis Apoptosis-inducing agent and method for inducing apoptosis

2011-03-01

2011-03-01

Carlson, Karen Cochrane (Department: 1656)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S350000

Reexamination Certificate

active

07897562

ABSTRACT:
An object of the present invention is to provide a novel means for stably and surely inducing cell apoptosis using the c-myc gene as a target. The present invention relates to an apoptosis-inducing agent containing a protein that interacts with an FBP protein or a polynucleotide encoding the protein as an active ingredient and a method for inducing apoptosis, which comprises a step of causing the apoptosis-inducing agent to come into contact with cells.

REFERENCES:
patent: 01/96873 (2001-12-01), None
Liu et al. 2000; The FBP interacting repressor targets TFIIH to inhibit activated transcription. Molecular Cell 5: 331-341.
Bouffard et al. 2000; Interaction cloning and characterization of RoBPI, a novel protein binding to human Ro ribonucleoproteins. RNA 6: 66-78.
Thompson, E. B., “The Many Roles of c-Myc in Apoptosis,” Annual Review of Physiology, 1998, vol. 60, pp. 575-600.
Pelengaris et al.; “Suppression of Myc-Induced Apoptosis in Beta Cells Exposes Multiple Oncogenic Properties of Myc and Triggers Carcinogenic Progression” Cell, May 3, 2002, vol. 109, pp. 321-334.
Thiede et al.; “Predominant Identification of RNA-binding Proteins in FAS-induced Apoptosis by Proteome Analysis”, Journal of Biological Chemistry, Jul. 13, 2001, vol. 276, No. 28, pp. 26044-26050.
Brockstedt et al.; “Identification of Apoptosis-associated Proteins in a Human Burkitt Lymphoma Cell Line”, Journal of Biological Chemistry, Oct. 23, 1998, vol. 273, No. 43, pp. 28057-28064.
Supplementary European Search Report dated Jun. 15, 2009 for EP Appln. No. 04 72 4383.

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