Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1996-05-29
1998-11-10
McKelvey, Terry A.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435 701, 435 711, 435375, 435243, 530324, 530325, 530326, 530327, 530350, C12P 2102, C07K 708, C07K 1447, C12N 100, C12N 502
Patent
active
058342346
ABSTRACT:
The present invention is directed to an isolated Bbk protein, nucleotide sequences coding for and regulating expression of the protein, antibodies directed against the protein, and recombinant vectors and host cells containing the genetic sequences coding for and regulating the expression of the protein sequence. The invention is also directed to genomic DNA, cDNA, and RNA encoding the Bbk protein sequence and to corresponding antisense RNA sequences. Antibodies can be used to detect Bbk in biological specimens, including, for example, human tissue samples. The present invention is further directed to methods of treating degenerative disorders characterized in inappropriate cell proliferation or inappropriate cell death. The present invention is further directed to methods for diagnosing degenerative disorders characterized in inappropriate cell proliferation or inappropriate cell death, as well as methods for monitoring the progress of such degenerative disorders.
REFERENCES:
Boyd et al., Bik, a novel death-inducing protein shares a distinct sequent motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins. Oncogene. 02 Nov. 1995, vol. 11, No. 9, pp. 1921-1928.
Chittenden et al., A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions. The EMBO Journal. 15 Nov. 1995, vol. 14, No. 22, pp. 5589-5596.
Ngo et al., The Protein Folding Problem and Tertiary Structure Prediction, Mertz et al (eds.), Birkhauser, Boston, 1994, pp. 433 and 492-495.
Krontiris, Molecular and Cellular Biology of Cancer, Internal Medicine, 4th edition, Stein (ed.), pp. 699-715.
Immunogen Inc.
McKelvey Terry A.
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