Apoptosis-associated protein and use thereof

Details Apoptosis-associated protein and use thereof Apoptosis-associated protein and use thereof

2008-06-24

2008-06-24

Helms, Larry R. (Department: 1643)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C435S007210

Reexamination Certificate

active

07390625

ABSTRACT:
The present invention provides a partial peptide comprising the functional domain of a protein comprising an amino acid sequence which is the same or substantially the same as an amino acid sequence represented by SEQ ID NO:2 or SEQ ID NO: 4; a screening method and a kit therefor for a substance which regulates ASK1 activation, or a prophylactic or therapeutic substance for diseases associated with apoptosis or inflammation, which comprises using the protein or the partial peptide or a cell which produces the same, and optionally ASK1 or a partial peptide thereof or a cell which produces the same; and an agent for regulating apoptosis or inflammatory cytokine production, or a prophylactic or therapeutic agent for diseases associated with apoptosis or inflammation, which comprises a substance for regulating an activity of a protein comprising an amino acid sequence which is the same or substantially the same as an amino acid sequence represented by SEQ ID NO:2 or SEQ ID NO: 4.

REFERENCES:
patent: 6194187 (2001-02-01), Miyazono et al.
patent: 2004/0053233 (2004-03-01), Lorens et al.
patent: WO 99/57144 (1999-11-01), None
patent: WO02/38179 (2002-05-01), None
patent: WO03/063905 (2003-08-01), None
Burgess, Shaheen, Ravera, Jaye, Donohue, and Winkles. Possible dissociation of the heparin-binding and mitogenic activities of heparin-binding (acidic fibroblast) growth factor-1 from its receptor-binding activities by site-directed mutagenesis of a single lysine residue. 1990. Joural of Cell Biology, vol. 111, pp. 2129-2138.
Lazar, E., Watanabe, S., Dalton, S., and Sporn, M.B. Transforming growth factor a: mutation of aspartic acid 47 and leucine 48 results in different biological activites. 1988, Molecular and Cellular Biology, vol. 8, No. 3, pp. 1247-1252.
Schwartz, G.P., Burke, G.T., and Katsoyannis, P.G. A superactive insulin: [B10-Aspartic acid]insulin (human) 1987. Proceedings of the National Academy of Sciences, vol. 84, pp. 6408-6411.
Lin, M.C., Wright, D.E., Hruby, V.J., and Rodbell, M. Structure-function relationships in glucagon: properties of highly purified Des-His1-, Monoiodo-, and [Des-Asn28, Thr29](homoserine lactone27)-glucagon. 1975, Biochemistry, vol. 14 No. 8, pp. 1559-1563.
Hee-Sae Park et al., “Heat Shock Protein Hsp72 is a Negative Regulator of Apoptosis Signal-Regulating Kinase 1”, Molecular and Cellular Biology, Nov. 2002, 22:7721-7730.
In-Sik Hwang et al., “Interaction of ALG-2 with ASKI Influences ASK1 Localization and Subsequent JNK Activation”, FEBS Letter 529:183-187, 2002.
Takenori Takizawa et al., “Double-stranded RNA-activated Protein Kinase Interacts with Apoptosis Signal-regulating Kinase 1”, European Journal of Biochem, 269:6126-6132, 2002.
Xiangrong He et al., “ASK1 Associates with Troponin T and Induces Tropnin T Phosphorylation and Contractile Dysfunction in Cardiomyocytes”, American Journal of Pathology, 163:243-251, 2003.
Iizuk H., et al., Functional analysis of ABPI, a novel apoptosis-inducing factor with ASKI binding activity, The 25th Annual Meeting of the Molecular Biology Society of Japan Program and Abstracts, IP-1067 Dec. 11-14, 2002, Yokohama, Japan.
GenBank Database Accession No. AB041651, May 24, 2002.
GenBank Database Accession No. AF116272, Jun. 14, 1999.
Ichijo, et al., “Induction of Apoptosis by ASK1, a Mammalian MAPKKK That Activates SAPK/JNK and p38 Signaling Pathways,” Science, Jan. 3, 1997, vol. 275, pp. 90-94.
Leung, et al., “MRG15 Activates theB-mybPromoter through Formation of a Nuclear Complex with the Retinoblastoma Protein and the Novel Protein PAM14*,” Journal of Biological Chemistry, Oct. 19, 2001, vol. 276, No. 42, pp. 39171-39178.
Morita, et al., “Negative Feedback Regulation of ASK1 by Protein Phosphatase 5 (PP5) in Response to Oxidative Stress,” The EMBO Journal, 2001, vol. 20, No. 21, pp. 6028-6036.
Qureshi and Jackson, “Sequence-Specific DNA Binding by theS. shibataeTFIIB Homolog, TFB, and its Effect on Promoter Strength,” Molecular Cell, Feb. 1998, vol. 1, pp. 389-400.
Tobiume, et al., “Activation of Apoptosis Signal-Regulating Kinase 1 by the Stress-Induced Activating Phosphorylation of Pre-Formed Oligomer,” Journal of Cellular Physiology, 2002, vol. 191, pp. 95-104.
International Search Report, PCT/JP03/14794, Feb. 3, 2004.
European Search Report, PCT/JP0314794, Feb. 7, 2007.

Affiliated with

Also associated with

Rating

Apoptosis-associated protein and use thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Apoptosis-associated protein and use thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Apoptosis-associated protein and use thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2808889