Apoptin-associating protein

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Reexamination Certificate

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Details

C536S023100, C536S023500, C435S325000, C435S455000

Reexamination Certificate

active

06878692

ABSTRACT:
The invention relates to the field of apoptosis. The invention provides novel therapeutic possibilities, for example novel combinatorial therapies or novel therapeutic compounds that can work alone, sequentially to, or jointly with Apoptin, especially in those cases wherein p53 is (partly) non-functional.

REFERENCES:
patent: 0 921 192 (1999-06-01), None
patent: 0 924 296 (1999-06-01), None
Zhuang et al. Cancer Res 55(3):486-489 (Feb. 1995) “Apoptin, a protein derived from chicken anemia virus . . . ”.*
Pietersen et al. Gene Therapy 6:882-892 (1999) “ Specific tumor-cell killing with adenovirus . . . ”.*
Oorschot et al PNAS 94:5843-5847 (May 1997) “Apoptin induces apoptosis . . . ”.*
Bellamy, Christopher O.C., et al., “Cell death in health and disease: the biology and regulation of apoptosis,” Seminars in Cancer Biology, vol. 6, pp. 3-16 (1995).
Danen-Van Oorschot, A.A.A.M., et al., “Apoptin induces apoptosis in human transformed and malignant cells but not in normal cells.” Proc. Nat'l. Acad Sci. USA vol. 94, pp. 5843-5847 (May 1997).
Danen-van Oorschot, et al., A.A.A.M., “BAG-1 inhibits p53-induced but not apoptin-induced apoptosis,” Apoptosis, vol. 2, No. 4, pp 395-402 (1997).
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Noteborn, Mathieu H.M., et al, “Chicken Anemia Virus Induction of Apoptosis by a Single Protein of a Single-Stranded DNA Virus,” Seminars in Virology. vol 8, pp 497-504 (1998).
Noteborn, Mathieu H.M., et al., “Simultaneous expression of recombinant baculovirus-encoded chicken anaemia virus (CAV) proteins VP1 and VP2 is required for formation of the CAV-specific neutralizing epitope,” Journal of General Virology, vol. 79, pp. 3073-3077 (1998).
Paulovich, Amanda G , et al , “When Checkpoints Fail,” Cell, vol. 88, pp 315-321 (Feb. 7, 1997).
Steller Hermann, “Mechanisms and Genes of Cellular Suicide,” Science, vol. 267, pp 1445-1449 (Mar. 10, 1995).
Teodoro, Jose G , et al , “Regulation of Apoptosis by Viral Gene Products,” Journal of Virology, vol. 71, No 3, pp 1739-1746 (Mar. 1997).
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Partial European Search Report under Rule 46, paragraph 1 of the European Patent Convention.
Strausberg, Robert, “qy85c09.x1 NCI_CGAP_Brn25Homo sapienscDNA clone Image:2018800 3′, mRNA sequence”, Jan. 7, 1999, Accession No. AI360308.

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