Multicellular living organisms and unmodified parts thereof and – Nonhuman animal – Transgenic nonhuman animal
Patent
1998-04-30
2000-04-04
Crouch, Deborah
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
Transgenic nonhuman animal
800 3, 800 13, 800 14, 435325, 435455, C12N 500, C12N 1500, C12N 1585
Patent
active
060463813
ABSTRACT:
The present invention features non-human transgenic animal models for gene function, wherein the transgenic animal is characterized by having altered endogenous apolipoprotein E gene function and a transgene for an exogenous human apolipoprotein E isoform. The transgenic animals may be either homozygous or heterozygous for the transgene. The invention also features methods for using non-human transgenic animal models for the study of apolipoprotein E-mediated pathologies and the identification of compounds and therapies for such pathologies.
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Buttini Manuel
Mahley Robert W.
Mucke Lennart
Pitas Robert E.
Raber Jacob
Baker Anne-Marie
Crouch Deborah
DeVore Dianna L.
The Regents of the University of California
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