Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lipoproteins – e.g. – egg yolk proteins – cylomicrons – etc.
Reexamination Certificate
2003-07-23
2008-10-07
Weber, Jon P (Department: 1657)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lipoproteins, e.g., egg yolk proteins, cylomicrons, etc.
C530S361000, C424S094630
Reexamination Certificate
active
07432355
ABSTRACT:
The present invention provides isolated apolipoprotein E (apoE) stable folding intermediates. The invention further provides methods for identifying compounds that alter the structure or level or activity of an apoE stable folding intermediate, as well as methods of inhibiting the formation or activity of stable folding intermediates of apoE. The invention further provides methods for reducing the level and/or activity of an apoE stable folding intermediate, and methods for treating disorders relating to apoE4 in a subject.
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Morrow Julie A.
Weisgraber Karl H.
Borden Paula A.
Bozicevic Field & Francis LLP
Srivastava Kailash C
The J. David Gladstone Institutes
Weber Jon P
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