Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1997-04-08
1998-06-16
Hutzell, Paula K.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
5303879, 5303881, 5303911, 5303913, C07K 1600
Patent
active
057672482
ABSTRACT:
Methods of diagnosing or prognosing Alzheimer's disease in a subject are disclosed. The methods involve directly or indirectly detecting the presence or absence of an apolipoprotein E type 4 (ApoE4) isoform or DNA encoding ApoE4 in the subject. The presence of ApoE4 indicates the subject is afflicted with Alzheimer's disease or at risk of developing Alzheimer's disease. A novel immunochemical assay for detecting the presence or absence of the Apoliprotein E (ApoE) E4 allele in a subject is also disclosed.
REFERENCES:
patent: 5168045 (1992-12-01), Dyer et al.
patent: 5272055 (1993-12-01), Haley
patent: 5297562 (1994-03-01), Potter
Joachim et al.; "Antibodies to Non-beta Regions of the Beta-amyloid Precursor Protein Detect a Subset of Senile Plaques"; Amer. J. Pathology, 138:373-384 (1991).
G.C. Glenner and C.W. Wong; Alzheimer's Disease: Initial Report of the Purification and Characterization of a Novel Cerebrovascular Amyloid Protein, Biochemical and Biophysical Research Communications 120 pp. 885-890 (1984).
G.D. Schellenberg, et al; Association of an apolipoprotein CII allele with familial dementia of the Alzheimer type, Journal of Neurogeneics 4, pp. 97-108 (1987).
M. Emi, et al; Genotyping and Sequence Analysis of Apolipoprotein E Isoforms, Genomics 3, pp. 373-379 (1988).
A. Steinmetz et al; Confusion of Apolipoprotein E Phenotyping by Serum Amyloid A., Clin Chem 35, pp. 671-672 (1989).
H. Shimano, et al; Plasma apolipoproteins in patients with multi-infarct dementia, Atheroscierosis 79, pp. 257-260 (1989).
H. Maeda et al; Identification of Human Apolipoprotein E Variant Gene: Apolipoprotein E7 (Glu.sub.244,245 -LYS.sub.244, 245), The Journal of Biochemistry 105 No. 1, pp. 51-54 (1989).
J.E. Hixson et al; Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI, Journal of Lipid Research 31, pp. 545-548 (1990).
K. Kontula et al; Apotipoprotein E Polymorphism Determined by Restriction Enzyme Analysis of DNA Amplified by Polymerase Chain Reaction: Convenient Alternative to Phenotyping by Isoelectric Focusing, Clin. Chem 36, pp. 2087-2092 (1990).
D.J. Selkoe; The Molecular Pathology of Alzheimer's Disease, Neuron 6 pp. 487-498 (1991).
F. Wiederkehr; Analysis of cerebrospinal fluid proteins by electrophoresis; Journal of Chromatography 569 pp. 281-296 (1991).
P. Wenham et al; Apolipoprotein E genotyping by one-stage PCR, The Lancet 337, pp. 1158-1159 (1991).
M.A. Pericak-Vance, et al; Linkage Studies in Familial Alzheimer Disease: Evidence for Chromosome 19 Linkage; Am. J. Hum. Genet., 48 pp. 1034-1050 (1991).
Y. Namba et al; Apolipoprotein E. immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfield-Jakob disease: Brain Res. 541, pp. 163-166 (1991).
J.F. Diedrich, et al; Neuropathological Changes in Scrapie and Alzheimer's Disease are Associated with Increased Expression of Apolipoprotein E and Cathepsin D in Astrocytes; Jounal of Virology pp. 4759-4768 (1991).
K. Beyreuther and C.L. Masters, Amyloid Precursor Protein (APP) and .beta.A4 Amyloid in the Etiology of Alzheimer's Disease: Precursor-Product Relationships in the Derangement of Neuronal Function; Brain Pathology 1, pp. 241-251 (1991).
F. Tagliavini, et al; Alzheimer patients: preamyloid deposits are immunoreactive with antibodies to extracellular domains of the amyloid precursor protein; Neuroscience Letters 128, pp. 117-120 (1991).
C. Joachim, et al; Antibodies to Non-beta Regions of the Beta-amyloid Precursor Protein Detect a Subset of Senile Plaques; American Journal of Pathology 138 pp. 373-384 (1991).
K.S. Kosik; Alzheimer's Disease: A Cell Biological Perspective, Science 256, pp. 780-783 (1992).
J. Hardy; Genetic Mistakes Point the Way for Alzheimer's Disease, The Journal of NIH Research 5, pp. 46-49 (1993).
W.J. Strittmatter, et al; Apolipoprotein E: High-avidity binding to .beta.-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease; Proc. Natl. Acad. Sci. 90, pp. 1977-1981 (1993).
C. Zarow anc C.E. Finch; Abstract Apolipoprotein E Expression in Alzheimer's Disease and after Hippocampal Deafferentation in the Rat.
A.M. Saunders et al; Association of apolipoprotien E allel .epsilon.4 with late-onset familial and sporadic Alzheimer's disease, Neurology 43, pp. 1467-1472 (1993).
J. Travis, New Piece in Alzheimer's Puzzle, Science 261, pp. 828-829 (1993).
A.M. Saunders, et al; Apolipoprotein E .epsilon.4 allele distributions in late-onset Alzheimer's disease and in other amyloid-forming diseases, The Lancet 342, pp. 710-711 (1993).
J. Poirier, et al; Apolipoprotein E polymorphism and Alzheimer's disease, The Lancet 342, pp. 697-699 (1993).
W.J. Strittmatter et al; Binding of human apolipoprotein E to synthetic amyloid .beta. peptide: Isoform-specific effects and implications for late-onset Alzheimer's disease, Proc. Natl. Acad. Sci. 90, pp. 8098-8102 (1993).
D.E. Schmechel, et al; Increased amyloid .beta.-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease, Proc. Natl. Acad. Sci. 90, pp. 9649-9653 (1993).
E.H. Corder, et al; Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families, Science 261, pp. 921-923 (1993).
M. Waldholz, Clue to a Killer Alzheimer's is Linked to the Way the Blood Transports Cholesterol, Wall Street Journal Jun. 7, 1993.
A. Toufexis, Alzheimer's Clue: Once ignored, a scientist gains support for his idea that a common gene helps cause the disease, Time Jun. 21, 1993.
R. Mayeux, et al; The Apolipoprotein .epsilon.4 Allele in Patients with Alzheimer's Disease, Annal of Neurology 34; pp. 752-754, Nov. 1993.
Neurology Notes, Announcing the New ApoE GenoType Report, Genica Pharmaceuticals Corp. (1993).
A. Roses; The Alzheimer Diseases, Current Neurology 14, pp. 111-141 (1994).
G. Lucotte, et al; Apolipoprotein E-.epsilon.4 Allele Doses in Late-Onset Alzheimer's Disease, Annals of Neurology 36 No. 4, pp. 681-682 (1994).
L. Lannfelt, et al; Lack of Association between apolipoprotein E allele .epsilon.4 and sporadic Alzheimer's disease, Neuroscience Letters 169 pp. 175-178 (1994).
T. Yoshizawa, et al; Dose-dependent Association of Apolipoprotein E Allele .epsilon.4with Late-Onset, Sporadic Alzheimer's Disease, The American Neurological Association 36, No. 4, pp. 656-659 (1994).
P. Amouyel, et al; The Apolipoprotein E alleles as major susceptibility factors for Creutzfeldt-Jakob disease, The Lancet 344, pp. 1315-1318 (1994).
W.A. Kukull; Revision of reported APOE results, (Nov. 3, 1994)
Gerritse et al (1992) J. Lipid Res. 33:273-280. (Feb. issue).
Harlow et al. (1988) "Antibodies: A Laboratory Manual," Cold Spring Harbor Press, Cold Spring Harbor, N.Y., pp. 553-612 and 321-358.
Enghild Jan
Roses Allen D.
Salvesen Guy S.
Schmechel Donald E.
Strittmatter Warren J.
Duffy Patricia A.
Duke University
Hutzell Paula K.
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