Apolipoprotein-.beta. synthesis inhibitors

Details Apolipoprotein-.beta. synthesis inhibitors Apolipoprotein-.beta. synthesis inhibitors

1995-05-31

1996-05-28

Tsang, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544295, 544298, 544315, 544319, 544360, 544366, 544367, 544369, 544370, 5462837, 548127, 548129, 548182, 548213, 548225, 548228, 548229, 5482632, 5483421, A61K 31495, C07D41300, C07D41700, C07D40100

Patent

active

055211860

ABSTRACT:
The present invention provides novel compounds of formula ##STR1## the stereochemically isomeric forms thereof, and the pharmaceutically acceptable acid addition salts thereof, wherein A and B taken together form a bivalent radical of formula: --N.dbd.CH-- (a), --CH.dbd.N-- (b), --CH.sub.2 --CH.sub.2 -- (c), --CH.dbd.CH-- (d) --C(.dbd.O)--CH.sub.2 -- (e), --CH.sub.2 --C(.dbd.O)-- (f); R.sup.1 is hydrogen, C.sub.1-6 alkyl, or halo; R.sup.2 is hydrogen or halo; R.sup.3 is hydrogen; C.sub.1-8 alkyl; C.sub.3-6 cycloalkyl or C.sub.1-8 alkyl substituted with hydroxy, oxo, C.sub.3-6 cycloalkyl or aryl. Het is five- or six-membered optionally substituted heterocyclic ring. The use as a medicine, especially as a lipid lowering agent is disclosed as well as pharmaceutical compositions and processes for preparing compounds and compositions.

REFERENCES:
patent: 4267179 (1981-05-01), Heeres et al.
patent: 4931444 (1990-06-01), Van Wauwe et al.

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