Apolipoprotein analogues

Details Apolipoprotein analogues Apolipoprotein analogues

2005-05-24

2005-05-24

Weber, Jon (Department: 1653)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

Reexamination Certificate

active

06897039

ABSTRACT:
The invention relates to a pharmaceutical composition comprising an apolipoprotein construct, to an apolipoprotein construct, a nucleic acid sequence encoding the apolipoprotein construct, a vector comprising the nucleic acid sequence, a method for producing the apolipoprotein construct, and a method of treatment comprising administering the apolipoprotein construct. The presented data document that the constructs according to the invention are capable of binding lipids, are capable of binding cubilin, which is a strong Apo AI receptor, stronger than native Apo A-I and that the plasma half life of the constructs is at least tripled compared to native Apo A-I. Together these data document that the constructs according to the invention are strong candidates for treatment of cardiovascular diseases.

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Sirtori et al,Recombinant apolipoproteins for the treatment of vascular disease, Atherosclerosis, vol. 142, pp. 29-40, Jan. 1999.
Kluft, et al.,Functional Analogy Between Lipoprotein(a)and Plasminogen in the Binding to the Kringle 4 Binding Protein, Tetranectin, Biochemical and Biophysical Research Communications, vol. 161, No. 2, pp. 427-433, Jun. 15, 1989.

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