Apo-transferrin as a potent inhibitor of bacterial adhesion to b

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert

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Details

424489, 424491, A61F 1300, A61K 914, A61K 916

Patent

active

061269557

ABSTRACT:
Methods of inhibiting bacterial adhesion to medical implants and reducing device-associated infection are effectuated by administering an effective amount of apo-transferrin to an individual with such an implant. Preferably the apo-transferrin is administered by controlled release at or near the implant.

REFERENCES:
patent: 5753506 (1998-05-01), Johe
patent: 5811447 (1998-09-01), Kunz et al.
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Modun et al., The Staphylococcus Aureus and Staphylococcus epidermidis transfferin-binding protiens are expressed in vivo during infection, Microbiology, 1350-0872, Abstract, Apr. 1998.
P.E. Vaudaux et al., Use of Adhesion-Defective Mutants of Staphylococcus aureus To Define the Role of Specific Plasma Proteins in Promoting Bacterial Adhesion to Canine Arteriovenous Shunts, 63 Infection and Immunity 585-590 (1995).
W.M. Artis et al., Fungistatic Mechanism of Human Transferrin for Rhizopus oryzae and Trichophyton mentagrophytes: Alternative to Simple Iron Deprivation, 41 Infection and Immunity 1269-1278 (1983).
R.T. Ellison III et al., Lactoferrin and transferrin damage of the Gram-negative outer membrane is modulated by Ca.sup.2 + and Mg.sup.2 +, 136 Journal of General Microbiology 1437-1446 (1990).
R.T. Ellison III et al., Damage of the Outer Membrane of Enteric Gram-Negative Bacteria by Lactoferrin and Transferrin, 56 Infection and Immunity 2774-2781 (1988).
P. Williams & E. Griffiths, Bacterial transferrin receptors--structure, function and contribution to virulence, 181 Medical Microbiology and Immunology 301-322 (1992).
D.E. Benson et al., Effects of Plasma on Adhesion of Biofilm Forming Pseudomonas aeruginosa an Staphylococcus epidermidis to Fibrin Substrate, 42 ASAIO Journal M655-M660 (1996).

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