Apo-2 ligand

Details Apo-2 ligand Apo-2 ligand

2006-02-14

2006-02-14

Romeo, David S. (Department: 1647)

Drug, bio-affecting and body treating compositions

Lymphokine

C530S350000, C530S402000, C930S140000, C514S012200

Reexamination Certificate

active

06998116

ABSTRACT:
A novel cytokine, designated Apo-2 ligand, which induces mammalian cell apoptosis is provided. The Apo-2 ligand is believed to be a member of the TNF cytokine family. Compositions including Apo-2 ligand chimeras, nucleic acid encoding Apo-2 ligand, and antibodies to Apo-2 ligand are also provided. Methods of using Apo-2 ligand to induce apoptosis and to treat pathological conditions such as cancer, are further provided.

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