Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Animal cell – per se – expressing immunoglobulin – antibody – or...
Patent
1997-01-08
2000-04-04
Spector, Lorraine
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Animal cell, per se, expressing immunoglobulin, antibody, or...
5303881, 53038824, 530350, 435335, 435336, 536 235, C12N 516
Patent
active
060460482
ABSTRACT:
A novel cytokine, designated Apo-2 ligand, which induces mammalian cell apoptosis is provided. The Apo-2 ligand is believed to be a member of the TNF cytokine family. Compositions including Apo-2 ligand chimeras, nucleic acid encoding Apo-2 ligand, and antibodies to Apo-2 ligand are also provided. Methods of using Apo-2 ligand to induce apoptosis and to treat pathological conditions such as cancer, are further provided.
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Ashkenazi Avi J.
Chuntharapai Anan
Kim Kyung Jin
Genetech, Inc.
Lazar-Wesley Eliane
Marschang Diane L.
Spector Lorraine
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