Apidaecin-type peptide antibiotics with improved activities and/

Details Apidaecin-type peptide antibiotics with improved activities and/ Apidaecin-type peptide antibiotics with improved activities and/

1994-03-02

1995-11-14

Patterson, Jr., Charles L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 14, 530326, 530327, A01N 6302, A61K 3810, C07K 700, C07K 708

Patent

active

054666716

ABSTRACT:
This invention provides a purified polypeptide having antibacterial activity comprising a first sequence Pro-Arg-Pro-Pro-His-Pro-Arg-X1, wherein X1 is Ile or Leu; and a second sequence X2-Pro-X3-X4-X5-Pro, wherein X2 is Arg or Lys, X3 is Thr, Gln or Arg, X4 is Tyr, Gln or Pro, and X5 is Val or Ala, the second sequence is N-terminal to the first sequence. This invention also provides a purified polypeptide having antibacterial activity comprising: a first sequence, at least seven amino acid residues are the same as Pro-Arg-Pro-Pro-His-Pro-Arg-X1, wherein X1 is Ile or Leu; a second sequence X2-Pro-X3-X4X5-Pro, wherein X2 is Arg or Lys, X3 is Thr, Gln or Arg, X4 is Tyr, Gln or Pro, and X5 is Val or Ala, the second sequence is N-terminal to the first sequence; and a third sequence comprising at least five amino acid residues, at least one-third of the residues are Pro, the third sequence is N-terminal to the second sequence.

REFERENCES:
patent: 5300629 (1994-04-01), Casteels et al.
Keppi, et al., C.R. Acad. Sc. Paris (1986) 303(5): 155-160.
P. van Hofsten, et al., Proc. Natl. Acad. Sci.--USA (Apr. 1985) 82(8): 2240-2243.
Andreu, et al., Proc. Natl. Acad. Sci.--USA (Nov. 1983) 80(21):6475-6479.
Dimarcq, et al., Euro. Jour. of Bioch. (Jan. (II) 1988) 171(1/2): 17-22.
Casteels--Josson, et al., The EMBO Journal (1993) 12(4): 1569-1578.
Boman and Hultmark, Annual Review of Microbiology (1987) 41: 103-126.
Jaynes, et al., BioEssays (Jun. 1987) 6(6): 263-270.
Zasloff, Proc. Natl. Acad. Sci. U.S.A. 84:5449-5453 (1987).

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