Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1998-02-13
2000-01-11
Fredman, Jeffrey
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 6, 436500, 530350, 5303871, 5303881, G01N 3353, C07K 1528, C07K 500
Patent
active
060134615
ABSTRACT:
During routine screening of a patient with a family history of colorectal cancer for truncating APC mutations, a novel missense mutation was identified. Upon further evaluation, it was found that 6% of Ashkenazi Jews carry this mutation, and that it was present in .sup..about. 20% of Ashkenazis with a family history of CRC. Probes, methods, and kits for identifying individuals affected with this missense mutation are provided.
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Gruber Stephen
Kinzler Kenneth
Laken Steve
Petersen Gloria
Vogelstein Bert
Fredman Jeffrey
The Johns Hopkins University
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