APC gene and nucleic acid probes derived therefrom

Details APC gene and nucleic acid probes derived therefrom APC gene and nucleic acid probes derived therefrom

1996-10-04

2000-05-23

Fitzgerald, David L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 2431, 536 2433, 536 231, 435 6, 935 6, 935 8, 935 9, C12N 1512, C07K 14435, C12Q 0168

Patent

active

RE0367133

ABSTRACT:
A human gene termed APC is disclosed. Methods and kits are provided for assessing mutations of the APC gene in hum tissues and body samples. APC mutations are found in familial adenomatous polyposis patients as wel as in sporadic colorectal cancer patents. APC is expressed in most normal tissue. These results suggest that APC is a tumor suppressor.

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Stanbridge, et al., Science, vol. 247, pp. 12-13, 1990.
Bodmer et al., 1987 Nature 328:614.
Fearen et al 1990 Science 247:49.
Baker et al. 1989 Science 244:217.

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