APC gene and nucleic acid probes derived therefrom

Details APC gene and nucleic acid probes derived therefrom APC gene and nucleic acid probes derived therefrom

1991-08-08

1994-10-04

Hill, Jr., Robert J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

935 8, 935 9, 435 6, C07H 2100, C12Q 168

Patent

active

053527755

ABSTRACT:
A human gene termed APC is disclosed. Methods and kits are provided for assessing mutations of the APC gene in human tissues and body samples. APC mutations are found in familial adenomatous polyposis patients as well as in sporadic colorectal cancer patients. APC is expressed in most normal tissues. These results suggest that APC is a tumor suppressor.

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Stanbridge, et al., Science, vol. 247, pp. 12-13, 1990.
Bodmer et al. 1987 Nature 328:614.
Fearen et al 1990 Science 247:49.
Baker et al. 1989 Science 244:217.

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