APC Antibodies

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

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C530S388200, C530S387900, C530S388800, C530S389700, C536S023500, C424S130100, C424S138100, C424S141100, C424S174100

Reissue Patent

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RE038916

ABSTRACT:
A human gene termed APC is disclosed. Methods and kits are provided for assessing mutations of the APC gene in human tissues and body samples. APC mutations are found in familial adenomatous polyposis patients as well as in sporadic colorectal cancer patients. APC is expressed in most normal tissues. These results suggest that APC is a tumor suppressor.

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patent: WO 89/01481 (1988-08-01), None
Kinzler et al., “Identification of FAP Locus Genes from Chromosome 5q21”, Science 253: 661-665, 1991.
Groden et al., “Identification and Characterization of the familial Adenomatous Polyposis Coli Gene”, Cell 66:589-600 (1991).
Joslyn et al. “Identification of Deletion Mutations and Three New Genes at the Familial Polyposis Locus” Cell, 66:601-613 (1991).
Nishisho et al., “Mutations of Chromosome 5q21 Genes in FAP and Colorectal Cancer Patients” Science, 253:665-669 (1991).
Orita et al., Genomics, vol. 5, pp. 874-879, 1989.
Stanbridge et al., “Identifying Tumor Suppressor Genes in Human Colorectal Cancer”, Science 247:12-13 (1990).
Fearon et al., “Identification of a Chromosome 18q Gene that is Altered in Colorectal Cancer” Science 247:49-56 (1990).
Baker et al., “Chromosome 17 Deletions and p53 Gene Mutations in Colorectal Carcinomas”, Science, 244:217-221 (1989).
Bodmer et al. “Localization of the Gene for familial Adenomatous Polyposis of Chromosome 5” Nature 328:614-616 (1987).

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