APC antibodies

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

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5303879, 5303888, 5303897, 536 235, C07K 1632, C12N 512, C12N 1512

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active

056914547

ABSTRACT:
A human gene termed APC is disclosed. Methods and kits are provided for assessing mutations of the APC gene in human tissues and body samples. APC mutations are found in familial adenomatous polyposis patients as well as in sporadic colorectal cancer patients. APC is expressed in most normal tissues. These results suggest that APC is a tumor suppressor.

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Kinzler et al, Science 253: 661-665, 1991.
Groden, et al., "Identification and Characterization of the Familial Adenomatous Polyposis Coli Gene", Cell, 66:589-600 (1991).
Joslyn, et al., "Identification of Delection Mutations and Three New Genes at the Familial Polyposis Locus", Cell, 66:601-613 (1991).
Kinzler, et al., "Identification of FAP Locus Genes From Chromsome 5q21", Science, 253:661-665 (1991).
Nishisho, et al., "Mutations of Chromosome 5q21 Genes in FAP and Colorectal Cancer Patients", Science, 253:665-669 (1991).
Orita, et al., Genomics, vol. 5, pp. 874-879, 1989.
Stanbridge, et al., "Identifying Tumor Suppressor Genes in Human Colorectal Cancer", Science, 247:12-13 (1990).
Fearon et al., "Identification of a Chromosome 18q Gene That is Altered in Colorectal Cancer", Science, 247:49-56 (1990).
Baker et al., "Chromosome 17 Deletions and p53 Gene Mutations in Colorectal Carcinomas", Science, 244:217-221 (1989).
Bodmer et al., "Localization of the Gene for Familial Adenomatous Polyposis on Chromosome 5", Nature, 328:614-616 (1987).

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