Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant or stably-transformed bacterium encoding one or...
Patent
1975-10-08
1978-06-27
Rose, Shep K.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Recombinant or stably-transformed bacterium encoding one or...
A61K 31165, A61K 4700
Patent
active
040976068
ABSTRACT:
APAP tablet containing from about 190 to 1000 milligrams of APAP, from 25 to 100 milligrams of an alkali metal salt of a low substituted carboxymethyl starch such as sodium or potassium, and preferably sodium and, optionally, a non-toxic pharmaceutically acceptable binder in a quantity equal to or less than the amount of APAP in the tablet. Several methods are described for preparing these tablets.
REFERENCES:
patent: 3034911 (1962-05-01), McKee et al.
patent: 3079303 (1963-02-01), Raff et al.
patent: 3266992 (1966-08-01), De Jong
patent: 3424842 (1969-01-01), Nurnberg
patent: 3490742 (1970-01-01), Nichols
patent: 3622677 (1971-11-01), Short et al.
patent: 3632778 (1972-01-01), Sheth et al.
patent: 3946110 (1976-03-01), Hill
patent: 4013785 (1977-03-01), Weintraub et al.
"Primojel" Edward Mendell Co. Inc. Tech. Bull., May 1972, An Evaluation of Carboxymethyl Starch as a Tablet Disintegrant, Nov. 1970, Determination of the Efficacy of Primojel as a Disintegrating Agent in Several Compressed Pharmaceutical Tablet Formulations (60 seconds disintegration-84% emcompress-10% APAP-5% Primojel).
Jaminet et al., Pharmaceutica Acta Helvetiae, 44:418-432 (1969).
Khan et al., J. Pharm. Pharmac. 23 Suppl. pp. 261S-262S (1971), An Evaluation of Five Commercially Available Tablet Disintegrants for Possible Use in Insoluble Direct Compression Systems.
Reier et al., Chem. Abstracts 64 #19327d (1966) of J. Pharm. Sci. 55(5): 510-514 (1966), "Micro-Crystalline Cellulose in Tableting".
Merck Index, 8th ed. (1968), p. 5, entry "Acetaminophen" APAP.
Chavkin Leonard
Merkle F. Henry
Bristol-Myers Company
Holtzman Irving
Mentis George A.
Mugford David J.
Rose Shep K.
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