Aotus interspecies hybridomas and monoclonal receptors produced

Details Aotus interspecies hybridomas and monoclonal receptors produced Aotus interspecies hybridomas and monoclonal receptors produced

1984-10-12

1988-05-24

Moskowitz, Margaret

Chemistry: molecular biology and microbiology

Spore forming or isolating process

435 68, 435 70, 4351722, 935 96, 935100, 935103, 935102, 530350, 530387, 530388, C12N 500, C12N 1500, C07K 1504

Patent

active

047466120

ABSTRACT:
Aotus trivirgatus interspecies hybridomas, their monoclonal receptors and methods of preparation and use are disclosed. The hybridomas are prepared by fusion of Aotus antibody-producing cells with myeloma cells containing about an equal number of chromosomes per cell. The resulting hybridomas are stable and secrete Aotus receptors. Particular receptors that immunoreact with antigenic proteins of Plasmodium falciparum shizonts and merozoites are disclosed.

REFERENCES:
patent: 4466917 (1984-08-01), Nussenzweig
Holder, A. A. et al., J. Exper. Medicine 156:1528-1538 (11-1982).
Reese, R. T. et al., Am. J. Trop. Med. Hyg. 30:1168-1178 (1981).
Holder, A. A. et al., J. Exper. Medicine 160:624-629 (8-1984).
Kearney, J. F. et al., J. Immunology 123:1548-1550 (10-1979).
Buck, D. W. et al., Monoclonal Antibodies and Functional Cell Lines, R. H. Kennett et al., eds., Plenum Publ. (1984), pp. 275-309.

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