Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ortho-hydroxybenzoic acid or derivative doai
Patent
1989-12-04
1990-06-26
Schwartz, Richard A.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ortho-hydroxybenzoic acid or derivative doai
514299, 514304, 514305, A61K 31625
Patent
active
049372360
ABSTRACT:
A method of treating anxiety including administering to a person to be treated an effective amount of compounds of the general formula: ##STR1## wherein the various substituents are defined hereinbelow have pharmacological properties rendering them useful as antiemetic agents with reduced undesirable side-effects or as anxiolytic agents. Various methods are described for their preparation involving formation of the amide link, etherification of the 2-hydroxy derivative, introducing the R.sup.5 CH.sub.2 group on the N-unsubstituted azabicyclooctane or nonane or, for 4-amino compounds, by hydrolysing a 4-acylamino derivative.
REFERENCES:
patent: 4820715 (1989-04-01), Monkovic et al.
Mauri Jacinto M.
Noguera Fernando P.
Soto Jose M. P.
Spickett Robert G. W.
Vega-Noverola Armando
Fordonal, S.A.
Schwartz Richard A.
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