Anxiolytic 4,5-dihydro-4-oxo-1H-imidazol-2-yl urea derivatives

Details Anxiolytic 4,5-dihydro-4-oxo-1H-imidazol-2-yl urea derivatives Anxiolytic 4,5-dihydro-4-oxo-1H-imidazol-2-yl urea derivatives

1985-05-24

1987-04-14

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548311, A61K 31415, C07D23388

Patent

active

046579222

ABSTRACT:
Ureas of the formula (I): ##STR1## where R.sup.1 =alkoxy or alkylthio; R.sup.2 =alkyl; and Ar=substituted or unsubstituted phenyl, useful as anxiolytic agents as well as intermediates useful in the synthesis.

REFERENCES:
patent: 3983135 (1976-09-01), Rasmussen
patent: 4230713 (1980-10-01), Bare
"ASMS 32nd Annual Conference on Mass Spectrometry and Allied Topics", May 27-Jun. 1, 1984, San Antonio, Tex., p. 48, Chmeda, et al.
"American Chemical Society Division of Medicinal Chemistry", 188th ACS National Meeting, Aug. 26-31, 1984, Philadelphia, Pa., Symposium on Fluoride-Containing Materials of Medicinal Importance, Arakali, et al., Abstract No. 65.

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