Chemistry: molecular biology and microbiology – Treatment of micro-organisms or enzymes with electrical or... – Modification of viruses
Patent
1979-09-18
1982-01-19
Tanenholtz, Alvin E.
Chemistry: molecular biology and microbiology
Treatment of micro-organisms or enzymes with electrical or...
Modification of viruses
435253, 435820, 424 92, C12N 1500
Patent
active
043117970
ABSTRACT:
An E. coli strain producing metabolically active but non-reproductive, anucleated live cells, which contain the K99 surface antigen, is obtained by transferring the K99 plasmid from a K99+ entero pathogenic E. coli strain into an E. coli strain which generates progeny of cells that lack the ability to multiply. From the resulting E. coli strain a "live" vaccine is prepared. Separation and purification of the anucleated live cells from growing cells is the basis for the "live" and chemically and/or physically unmodified vaccine. The vaccine induces the production of antibodies against growing and infective enteropathogenic K99+ E. coli in cattle and is, thus effective against coliform enteritis.
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Lewin, Gene Expression, John Wiley & Sons, vol. 3, pp. 140-142, (1977).
Beale et al, Extranuclear Genetics, University Park Press, pp. 71 and 72 (1978).
Tanenholtz Alvin E.
University of Saskatchewan
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