Antracycline antineoplastic agents encapsulated in phospholipid

Details Antracycline antineoplastic agents encapsulated in phospholipid Antracycline antineoplastic agents encapsulated in phospholipid

1987-10-26

1988-09-06

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

424491, 424493, 514908, A61K 950

Patent

active

047692502

ABSTRACT:
Formulations consisting of phospholipid bilayer membrane particles made from mixtures of anionic and neutral phospholipids encapsulating anthracycline anti-neoplastic agents, suspended in a low ionic strength aqueous phase, are described. In a preferred embodiment, the particles are in the form of vesicles which comprise daunorubicin, distearoyl phosphatidylglycerol and distearoyl phosphatidylcholine, the mol ratio of daunorubicin to distearoyl phosphatidylglycerol is at least about 1:1.25, and the suspending medium is an aqueous lactose solution containing a small amount of base.

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