Antivirals

Details Antivirals Antivirals

2006-12-12

2006-12-12

Saeed, Kamal A. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C546S286000, C546S309000, C514S344000, C514S352000

Reexamination Certificate

active

07148243

ABSTRACT:
Compounds of the formula I:whereinRxis cyano or bromo;R1is halo;R2is C114 C3alkyl,and pharmaceutically acceptable salts and prodrugs thereof have activity as antiretrovirals.

REFERENCES:
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patent: 6486183 (2002-11-01), Salhberg et al.
Silverman, Richard B., “Chapter 8: Prodrugs and Drug Delivery Systems” from “The Organic Chemistry of Drug Design and Drug Action,” Academic Press, Inc., pp. 352-358.
Naesens, Lieve et al. “Antiretroviral Efficacy and Pharmacokinetics of Oral Bis(isopropyloxycarbonzyloxymethyl)-9-(2-Phosphonylmethoxypropy!)adenine in Mice,” Antimicrobial Agents and Chemotherapy, Jul. 1998, vol. 42(7), pp. 1568-1573.
Optimization of Antiviral and Kinetic Prop ICAR Sante Fe 1995 23-28/04/1995 Overview.
Synthesis and HIV-1 activities of Urea-PETT analogues, belonging to a New Series of Potent Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors Poster XIV Int.Symp Med Chem Maastricht Sep. 8-12, 1996.
The Merck Manual, Fifteenth Edition, pp. 2437-2438, Published By Merck & Co., Inc. 1987.

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