Antiviral therapy using ovine or bovine interferon-tau

Drug – bio-affecting and body treating compositions – Lymphokine – Interferon

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

435 6951, A61K 3821, C12N 1520, C07K 14555

Patent

active

059422238

ABSTRACT:
The invention provides antiviral therapeutic methods employing bovine or ovine interferon-tau (IFN-.tau.) proteins and polypeptides. The IFN-.tau. proteins exhibit the antiviral and antiproliferative properties characteristic of type I interferons. An advantage of the invention is that IFN-.tau. has essentially no cytotoxic effects on treated cells as does, for example, IFN-.alpha..

REFERENCES:
patent: 4997646 (1991-03-01), Hansen et al.
patent: 5019382 (1991-05-01), Cummins
Imakawa, K., et al. (1987) J. Cell Biol. 105(4, part 2) : 11A, abst. No. 49.
Charpigny, G., et al. (1988) FEBS Lett. 228: 12-16.
Bazer, F.W., and Johnson, H.M., "Type I Conceptus Interferons: Maternal Recognition of Pregnancy Signal and Potential Therapeutic Agents", American J. of Reproductive Immun. 26:19-22 (1991).
Bazer, F.W., et al., "Roles of Ovine Trophoblast Protein-1 and Oestradiol/ Prolactin in the Establishment of Pregnancy in Sheep and Pigs", Reprod. Fertil. Dev. 4:335-340 (1992).
Farin, C.E., et al., "Expression of Trophoblastic Interferon Genes in Sheep and Cattle", Biol. of Reprod. 43:210-218 (1990).
Hansen, T.R., et al., "Complex Binding of the Embryonic Interferon, Ovine Trophoblast Protein-1, to Endometrial Receptors", J. Interferon Res. 9:215-225 (1989).
Hansen, T.R., et al., "The Genes for the Trophoblast Interferons and the Related Interferon-.alpha..sub.II Posses Distinct 5'-Promoter and 3'-Flanking Sequence", J. Biol. Chem. 266(5):3060-3067 (1991).
Imakawa, K., et al., "Interferon-like sequence of ovine trophoblast protein secreted by embryonic trophectoderm", Nature 330:377-379 (1987).
Imakawa, K., et al.,"Molecular Cloning and Characterization of Complementary Deoxyribonucleic Acids Corresponding to Bovine Trophoblast Protein 1: A Comparison with Ovine Trophoblast Protein-1 and Bovine Interferon-.alpha..sub.II ", Mol. Endocrin. 3(1):127-139 (1989).
Leaman, D.W., et al., "Genes for the Trophoblast Interferons and their Distribution among Mammals", Reprod. Fertil. Dev. 4:349-353 (1992).
Leaman, D.W., and Roberts, R.M., "Genes for the Trophoblast Interferons in Sheep, Goat, and Musk Ox and Distribution of Related Genes Among Mammals", J. Interferon Res. 12:1-11 (1992).
Newton, G.R., et al., "Inhibition of Lymphocyte Proliferation by Ovine Trophoblast Protein-1 and a High Molecular Weight Glycoprotein Produced by the Peri-Implantation Sheep Conceptus", Am. J. Reprod. Immunol. 19:99-107 (1989).
Ott, T.L., et al., "Cloning and Expression in Saccharomyces cerevisiae of a Synthetic Gene for the Type-I Trophoblast Interferon Ovine Trophoblast Protein-1: Purification and Antiviral Activity", J. Interferon Res. 11:357-364 (1991).
Pontzer, C.H., et al., "Antiviral Activity of the Pregnancy Recognition Hormone Ovine Trophoblast Protein-1", Biochem. and Biophys. Res. Commun. 152(2):801-807 (1988).
Pontzer, C.H., et al., "Localization of an antiviral site on the pregnancy recognition hormone, ovine trophoblast protein-1", Proc. Natl. Acad. Sci. USA 87:5945-5949 (1990).
Pontzer, C.H., et al., "Antiproliferative Activity of a Pregnancy Recognition Hormone, Ovine Trophoblast Protein-1", Cancer Res. 51:5304-5307 (1991).
Roberts, R.M., et al., "Interferons at the placenta interface", J. Reprod. Fert., Suppl. 41:63-74 (1990).
Roberts, R.M., et al., "Unique Features of the Trophoblast Interferons", Pharmac. Ther. 51:329-345 (1991a).
Roberts, R.M., et al., "The polypeptides and genes for ovine and bovine trophoblast protein-1", J. Reprod. Fert., Suppl. 43:3-12 (1991b).
Roberts, R.M., et al., "Interferons as Hormones of Pregnancy", Endocrine Rev. 13(3):432-452 (1992).
Tuo, W., et al., "Natural Killer Cell Activity of Lymphocytes Exposed to Ovine, Type I, Trophoblast Interferon", AJRI 29:26-34 (1993).
Vallet, J.L., et al., "The Effect of Ovine Trophoblast Protein-One on Endometrial Protein Secretion and Cyclic Nucleotides", Biol. Reprod. 37:1307-1316 (1987).
Vallet, J.L., et al., "Effect of ovine conceptus secretory proteins and purified ovine trophoblast protein-1 on interoestrous interval and plasma concentrations of prostaglandins F-2.alpha. and E and 13,14-dihydro-15-keto-prostaglandin F-2.alpha. in cyclic ewes", J. Reprod. Fert. 84:493-504 (1988).
Whaley, A.E., et al., "Molecular Cloning of Unique Interferons from Human Placenta," in Society of Reproduction, 24th Annual Meeting, p. 186 (1991).
Yong, K., et al., "Insulin-Like Growth Factors in Sheep Uterine Fluids: Concentrations and Relationship to Ovine Trophoblast Protein-1 Production during Early Pregnancy", Biol. Reprod. 45:135-142 (1991).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Antiviral therapy using ovine or bovine interferon-tau does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antiviral therapy using ovine or bovine interferon-tau, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antiviral therapy using ovine or bovine interferon-tau will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-464286

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.