Antiviral reagents based on RNA-binding proteins

Details Antiviral reagents based on RNA-binding proteins Antiviral reagents based on RNA-binding proteins

1991-12-13

2000-05-16

Carlson, Karen Cochrane

Chemistry: molecular biology and microbiology

Virus or bacteriophage, except for viral vector or...

530320, 530325, 530826, C12N 700, C07K 1400

Patent

active

060636122

ABSTRACT:
The present invention describes the generation of site-directed RNA cleaving agents. These agents consist of RNA-binding proteins, or polypeptides derived thereof, which are modified to contain a moiety capable of cleaving RNA backbones. Alternatively, the agents are oligonucleotides having nuclease resistant backbones to which a moiety capable of cleaving RNA backbones has been attached. The present invention also describes a method of cleaving target RNA substrates using the cleaving agents described herein. Further, the invention describes a method for inhibiting RNA virus expression in infected cells.

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